| Catalog No. | Size | Price (USD) |
| 10108-R003-20 | 20 µL | $118.49 |
| 10108-R003-50 | 50 µL | $177.58 |
| 10108-R003-100 | 100 µL | $340.51 |
General Information
| Product name | Recombinant Anti-ACE2 Antibody, Rabbit Monoclonal |
| Validated applications | WB (FAQ Protocol), ELISA (FAQ Protocol), IP (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human ACE2 |
| Immunogen | Recombinant Human ACE2 Protein (Catalog#10108-H31H) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Human ACE2 (rh ACE2; Catalog#10108-H31H; NP_068576.1; Met1-Ser740). |
| Source | Monoclonal Rabbit IgG Clone #003 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-ACEH Antibody; Anti-UNQ868/PRO1885 Antibody
Image / Experimental Information
| Image 1 Description | AAnti-ACE2 rabbit monoclonal antibody at 1:500 dilution Lane A: K562 Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti- Rabbit IgG(H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size: 92 kDa |
| Image 1 Alt Text | Human ACE2 Western blot (WB) 30812 |
| Image 1 URL | Source image |
| Image 2 Description | AAnti-ACE2 rabbit monoclonal antibody at 1:500 dilution Lane A: K562 Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti- Rabbit IgG(H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size: 92 kDa |
| Image 2 Alt Text | Human ACE2 Immunoprecipitation(IP) 30813 |
| Image 2 URL | Source image |
Background Information
| Full Name | angiotensin I converting enzyme 2 |
| Description | Angiotensin-converting enzyme 2 (ACE2), a first homolog of ACE, regulates the renin angiotensin system (RAS) by counterbalancing ACE activity. Accumulating evidence in recent years has demonstrated a physiological and pathological role of ACE2 in the cardiovascular, renal and respiratory systems. ACE2 also has an important role in blood pressure control. This enzyme, an homolog of ACE, hydrolyzes angiotensin (Ang) I to produce Ang-(1-9), which is subsequently converted into Ang-(1-7) by a neutral endopeptidase and ACE. ACE2 releases Ang-(1-7) more efficiently than its catalysis of Ang-(1-9) by cleavage of Pro(7)-Phe(8) bound in Ang II. Thus, the major biologically active product of ACE2 is Ang-(1-7), which is considered to be a beneficial peptide of the RAS cascade in the cardiovascular system. A physiological role for ACE2 has been implicated in hypertension, cardiac function, heart function and diabetes, and as a receptor of the severe acute respiratory syndrome coronavirus. In the acute respiratory distress syndrome (ARDS), ACE, AngII, and AT1R promote the disease pathogenesis, whereas ACE2 and the AT2R protect from ARDS. Importantly, ACE2 has been identified as a key SARS-coronavirus receptor and plays a protective role in severe acute respiratory syndrome (SARS) pathogenesis. Furthermore, the recent explosion of research into the ACE2 homolog, collectrin, has revealed a new physiological function of ACE2 as an amino acid transporter, which explains the pathogenic role of gene mutations in Hartnup disorder. This review summarizes and discusses the recently unveiled roles for ACE2 in disease pathogenesis. |
| References |
|
title: Broad-spectrum inhibition of SARS-CoV-2 variants by dibutyl phthalate through allosteric disruption of Spike-ACE2 interface
authors: Jiafan Chen; Dekuan Guo; ...; Meiling Zhu
journal: Frontiers in Microbiology
date: 2026-01-27
pmid: 41674904
doi: 10.3389/fmicb.2025.1610775
cited_by_count: 1
techniques: Activity Assay; Binding Assay; Concentration Assay; Enzyme-linked Immunosorbent Assay; Fluorescence; Inhibition; Recombinant; Stable Transfection
bioz_score: 94
title: The NSP5, ORF6 and NSP13 of SARS-CoV-2 Cooperate to Modulate Inflammatory Cell Death Activation.
authors: Huan Wang; Mengdi Liang; ...; Min Zheng
journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)
date: 2025-08-14
pmid: 40810650
doi: 10.1002/advs.202503977
cited_by_count: 0
techniques: Incubation; Infection; Virus
bioz_score: 94
title: Bioengineered nanovesicles for efficient siRNA delivery through ligand-receptor-mediated and enzyme-controlled membrane fusion
authors: Lele Cui; Yongsheng Cui; ...; Peng Mi
journal: Nature Communications
date: 2025-07-04
pmid: 40615402
cited_by_count: 7
techniques: Conjugation Assay; Flow Cytometry; Immunofluorescence; Immunohistochemistry; Sequencing; Western Blot
bioz_score: 94
title: LL-37 Inhibits TMPRSS2-Mediated S2' Site Cleavage and SARS-CoV-2 Infection but Not Omicron Variants.
authors: Zhenfei Bi; Wenyan Ren; ...; Xiawei Wei
journal: Cell Proliferation
date: 2025-05-15
pmid: 40375579
cited_by_count: 1
techniques: Activity Assay; Incubation; Infection; Luciferase; Lysis; Protease Inhibitor; Real-time Polymerase Chain Reaction; Stripping; Stripping Membranes; Transgenic Assay; Western Blot
bioz_score: 94
title: SARS-CoV-2 infects neurons, astrocytes, choroid plexus epithelial cells and pericytes of the human central nervous system in vitro .
authors: Ruth Haverty; Janet McCormack; ...; Nicola F Fletcher
journal: The Journal of general virology
date: 2024-07-12
pmid: 38995681
doi: 10.1099/jgv.0.002009
cited_by_count: 17
techniques: Cell Culture; Neutralization; Recombinant; Staining
bioz_score: 94
title: Recreating the biological steps of viral infection on a cell-free bioelectronic platform to profile viral variants of concern.
authors: Zhongmou Chao; Ekaterina Selivanovitch; ...; Susan Daniel
journal: Nature Communications
date: 2024-07-03
pmid: 38961055
doi: 10.1038/s41467-024-49415-6
cited_by_count: 3
techniques: Concentration Assay; Passaging
bioz_score: 94
title: A dual-target SPR screening system for simultaneous ligand discovery of SARS-CoV-2 spike protein and its receptor ACE2 from Chinese herbs.
authors: Ying Zhang; Dongyao Wang; ...; Yifeng Chai
journal: Journal of Pharmaceutical and Biomedical Analysis
date: 2024-04-09
pmid: 38631070
doi: 10.1016/j.jpba.2024.116142
cited_by_count: 2
techniques: Recombinant
bioz_score: 94
title: Development of a SARS‐CoV‐2 neutralization assay based on a pseudotyped virus using a HIV system
authors: Ziteng Liang; Jincheng Tong; ...; Youchun Wang
journal: MedComm
date: 2024-03-22
doi: 10.1002/mco2.517
pmcid: 10959455
cited_by_count: 0
techniques: Comparison; Expressing; Infection; Neutralization; Recombinant; Selection; Titration; Western Blot
bioz_score: 94
title: A Suitable Membrane Distance Regulated by the RBD_ACE2 Interaction is Critical for SARS-CoV-2 Spike-Mediated Viral Invasion.
authors: Mengdan Wu; Wei Li; ...; Ying Lai
journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)
date: 2023-10-01
pmid: 37590389
doi: 10.1002/advs.202301478
cited_by_count: 4
techniques: Binding Assay; Cell Culture; Cell-Cell Fusion Assay; Concentration Assay; Expressing; Functional Assay; In Vitro; Incubation; Inhibition; Labeling; Membrane; Western Blot
bioz_score: 94
title: Influenza A virus modulates ACE2 expression and SARS-CoV-2 infectivity in human cardiomyocytes
authors: Qian Wu; Naresh Kumar; ...; Murugesan V.S. Rajaram
journal: iScience
date: 2022-12-02
pmid: 36474635
doi: 10.1016/j.isci.2022.105701
pmcid: 9715453
cited_by_count: 6
techniques: Activity Assay; Bicinchoninic Acid Protein Assay; Binding Assay; Control; Derivative Assay; Endpoint Dilution Assay; Enzyme-linked Immunosorbent Assay; Expressing; Flow Cytometry; Generated; Incubation; Infection; Isolation; Labeling; Microscopy; Protein Concentration; Quantitative RT-PCR; Recombinant; SDS Page; SYBR Green Assay; Saline; Selection; Software; Staining; Sterility; Two Tailed Test; Variant Assay; Virus; Western Blot
bioz_score: 94
title: Simian Immunodeficiency Virus Infection Mediated Changes in Jejunum and Peripheral SARS-CoV-2 Receptor ACE2 and Associated Proteins or Genes in Rhesus Macaques
authors: Nongthombam Boby; Xuewei Cao; ...; Bapi Pahar
journal: Frontiers in Immunology
date: 2022-02-25
pmid: 35281029
doi: 10.3389/fimmu.2022.835686
pmcid: 8914048
cited_by_count: 3
techniques: Activity Assay; Biomarker Assay; Concentration Assay; Expressing; Fluorescence; Immunofluorescence; Incubation; Infection; Isolation; Multiplex Assay; Negative Control; Quantitative RT-PCR; RNA Sequencing Assay; Real-time Polymerase Chain Reaction; Staining; Two Tailed Test
bioz_score: 94
title: A second functional furin site in the SARS-CoV-2 spike protein
authors: Yue Zhang; Li Zhang; ...; Youchun Wang
journal: Emerging microbes & infections
date: 2022-01-04
pmid: 34856891
doi: 10.1080/22221751.2021.2014284
pmcid: 8741242
cited_by_count: 35
techniques: Activation Assay; Expressing; Generated; Infection; Luciferase; Microscopy; Plasmid Preparation; Recombinant; SDS Page; Transfection; Transgenic Assay; Western Blot
bioz_score: 94
title: Sensing of cytoplasmic chromatin by cGAS activates innate immune response in SARS-CoV-2 infection
authors: Zhuo Zhou; Xinyi Zhang; ...; Jianwei Wang
journal: Signal transduction and targeted therapy
date: 2021-11-03
pmid: 34732709
doi: 10.1038/s41392-021-00800-3
pmcid: 8564796
cited_by_count: 68
techniques: Virus; Western Blot
bioz_score: 94
title: A synthetic nanobody targeting RBD protects hamsters from SARS-CoV-2 infection
authors: Tingting Li; Hongmin Cai; ...; Dianfan Li
journal: Nature Communications
date: 2021-07-30
pmid: 34330908
doi: 10.1038/s41467-021-24905-z
pmcid: 8324831
cited_by_count: 68
techniques: Binding Assay; Comparison; Expressing; Flow Cytometry; Incubation; Plasmid Preparation; Selection; Transduction; Western Blot
bioz_score: 94
title: Coinfection with influenza A virus enhances SARS-CoV-2 infectivity
authors: Lei Bai; Yongliang Zhao; ...; Ke Xu
journal: Cell Research
date: 2021-02-18
pmid: 33603116
doi: 10.1038/s41422-021-00473-1
pmcid: 7890106
cited_by_count: 170
techniques: CRISPR; Expressing; Imaging; Immunofluorescence; Infection; Laser-Scanning Microscopy; Quantitative RT-PCR; SYBR Green Assay; Transduction; Western Blot
bioz_score: 94
title: Development of Plant-Produced Recombinant ACE2-Fc Fusion Protein as a Potential Therapeutic Agent Against SARS-CoV-2
authors: Konlavat Siriwattananon; Suwimon Manopwisedjaroen; ...; Waranyoo Phoolcharoen
journal: Frontiers in Plant Science
date: 2021-01-07
pmid: 33584747
doi: 10.3389/fpls.2020.604663
pmcid: 7874119
cited_by_count: 36
techniques: Activity Assay; Binding Assay; Blocking Assay; Enzyme-linked Immunosorbent Assay; Expressing; Incubation; Indirect ELISA; Infection; Inhibition; Neutralization; Plasmid Preparation; Produced; Protein Purification; Purification; SDS Page; Staining; Western Blot
bioz_score: 94
title: Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction
authors: Hiroaki Katsura; Vishwaraj Sontake; ...; Purushothama Rao Tata
journal: Cell Stem Cell
date: 2020-10-21
pmid: 33128895
doi: 10.1016/j.stem.2020.10.005
pmcid: 7577733
cited_by_count: 402
techniques: Cell Culture; Derivative Assay; Electron Microscopy; Immunostaining; Infection; Isolation; Marker; Microscopy; Quantitative RT-PCR; Recombinant; SYBR Green Assay; Software; Staining
bioz_score: 94
title: Co-infection of influenza A virus enhances SARS-CoV-2 infectivity
authors: Bai Lei; Zhao Yongliang; ...; Xu Ke
journal: bioRxiv
date: 2020-10-14
doi: 10.1101/2020.10.14.335893
cited_by_count: 0
techniques: CRISPR; Expressing; Imaging; Immunofluorescence; Infection; Laser-Scanning Microscopy; Microscopy; Plasmid Preparation; Quantitative RT-PCR; Real-time Polymerase Chain Reaction; SYBR Green Assay; Transduction; Transfection; Western Blot
bioz_score: 94
title: Membrane Nanoparticles Derived from ACE2-rich Cells Block SARS-CoV-2 Infection
authors: Wang Cheng; Wang Shaobo; ...; Zhao Jinghong
journal: bioRxiv
date: 2020-08-12
doi: 10.1101/2020.08.12.247338
cited_by_count: 0
techniques: Binding Assay; Cell Culture; Enzyme-linked Immunosorbent Assay; Immunofluorescence; Incubation; Inhibition; Membrane; Microscopy; Modification; Recombinant; Staining; Western Blot
bioz_score: 94
title: Morphogenesis and cytopathic effect of SARS-CoV-2 infection in human airway epithelial cells
authors: Na Zhu; Wenling Wang; ...; Wenjie Tan
journal: Nature Communications
date: 2020-08-06
pmid: 32764693
pmcid: 7413383
cited_by_count: 213
techniques: Concentration Assay; Immunofluorescence; Infection; Marker; Staining
bioz_score: 94
title: Detection of the SARS-CoV-2 Nucleocaspid Protein (NP) Using Immunohistochemistry
authors: Zeqing Feng; Bo Diao; ...; Yongwen Chen
journal: Bio-protocol
date: 2020-01-01
doi: 10.21769/BioProtoc.5002
cited_by_count: 0
bioz_score: 94
