| Catalog No. | Size | Price (USD) |
| 207569-T08-50 | 50 µL | $147.96 |
| 207569-T08-100 | 100 µL | $251.64 |
| 207569-T08-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-CDC42EP2 Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human CDC42EP2 |
| Immunogen | E. coli-derived Human CDC42EP2 fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human CDC42EP2 fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-BORG1 Antibody; Anti-CEP2 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human CDC42EP2 in human kidney with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human CDC42EP2 Immunohistochemistry(IHC) 26563 |
| Image 1 URL | Source image |
Background Information
| Full Name | CDC42 effector protein 2 |
| Description | CEP2 (CDC42EP2) is a member of the CDC42 subfamily that belongs to the Rho family. The Rho family plays an important role in a variety of cellular processes including skeletal myogenesis. The expression of CEP2 increases significantly during C2C12 myogenesis. Overexpression of CEP2 could attenuate myoblast differentiation, while knockdown of CEP2 by siRNA results in enhancing myogenesis. Furthermore, CEP2 attenuates myoblast differentiation via suppression of muscle regulatory factors (MRFs) rather than influencing myoblast proliferation. CEP2 acts as a repressor during myogenesis, which provides new insights into the role of CEP2 in muscle development. The confocal fluorescent staining results confirmed that stretch-induced realignment of cells and rearrangement of microfilaments. Among the 84 genes screened, the protein expression level of Cdc42 effector protein-2 (encoded by CDC42EP2) was down-regulated. |
| References |
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