| Catalog No. | Size | Price (USD) |
| E27-12QG-10 | 10 µg | $515.43 |
| E27-12QG-50 | 50 µg | $1,729.93 |
| E27-12QG-500 | 500 µg | $3,907.16 |
General Information
| Validated applications | Kinase Assay |
| Formulation | Supplied as sterile 50 mM Tris-HCl, pH 7.5, 50-300mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25-1.0mM DTT, 0-0.1mM PMSF, 10-25% glycerol Please contact us for any concerns or special requirements. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Shipping | Enzymes are highly recommended to be shipped at frozen temperature with dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products. |
| Stability & Storage | Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Purity | For specific information on a given lot, see related technical data sheet. |
| Activity | For specific information on a given lot, see related technical data sheet. |
| Protein Construction | Recombinant human HER2 (L755S L869R) (676-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
| Expressed Host | Baculovirus-Insect Cells |
| Species | Human |
| Molecule Mass | ~115 kDa |
| Technical Data Sheet by Lot # | A4682-22 |
Synonyms: c-ERB-2 Protein, Human; c-ERB2 Protein, Human; CD340 Protein, Human; HER-2 Protein, Human; HER-2/neu Protein, Human; HER2 Protein, Human; MLN 19 Protein, Human; MLN-19 Protein, Human; MLN19 Protein, Human; NEU Protein, Human; NGL Protein, Human; p185(erbB2) Protein, Human; TKR1 Protein, Human; VSCN2 Protein, Human
Background Information
| Full Name | erb-b2 receptor tyrosine kinase 2 |
| Description | Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on. |
| Research Areas |
|
| Tags |
|
| References |
|
title: Acquired secondary HER2 mutations enhance HER2/MAPK signaling and promote resistance to HER2 kinase inhibition in breast cancer
authors: Arnaldo Marín; Abdullah Al Mamun; ...; Ariella B. Hanker
journal: Cancer Research
date: 2024-03-15
pmid: 37404061
doi: 10.1158/0008-5472.CAN-22-3617
pmcid: 10530374
cited_by_count: 14
techniques: Activation Assay; Binding Assay; Cell Analysis; Construct; Expressing; Fluorescence; Glo Assay; Inhibition; Mutagenesis; Stable Transfection; Staining; Western Blot
bioz_score: 92
MDSD
