| Catalog No. | Size | Price (USD) |
| T16-11G-10 | 10 µg | $515.43 |
| T16-11G-50 | 50 µg | $1,729.93 |
| T16-11G-500 | 500 µg | $3,907.16 |
General Information
| Formulation | Supplied as sterile 50 mM Tris-HCl, pH 7.5, 50-300mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25-1.0mM DTT, 0-0.1mM PMSF, 10-25% glycerol Please contact us for any concerns or special requirements. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Shipping | Enzymes are highly recommended to be shipped at frozen temperature with dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products. |
| Stability & Storage | Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Purity | For specific information on a given lot, see related technical data sheet. |
| Activity | For specific information on a given lot, see related technical data sheet. |
| Protein Construction | Recombinant human TRIO (2627-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
| Expressed Host | Baculovirus-Insect Cells |
| Species | Human |
| Molecule Mass | ~82 kDa |
| Technical Data Sheet by Lot # | A4602-3 U1583-5 |
Synonyms: ARHGEF23 Protein, Human; MEBAS Protein, Human; MRD44 Protein, Human; MRD63 Protein, Human; tgat Protein, Human
Background Information
| Description | TRIO, also known as triple functional domain protein, interfaces with cell surface receptors and small guanosine triphosphatases (GTPases) to regulate neuronal morphogenesis and synaptic function. TRIO is encoded by 57 coding exons (3097 amino acids) and contains several domains, including an N-terminal SEC14 domain, several spectrin repeats, two Dbl-homology-Pleckstrin-homology (DH-PH) Rho-guanine exchange factor (GEF) units, an Ig-like domain, and a C-terminal serine/threonine kinase domain. The serine/threonine kinase domain is presumed to be active but quite selective; both DH-PH Rho-GEF domains are enzymatically active. TRIO9S and TRIO9L are the major isoforms expressed in the mammalian cortex. |
| References |
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MDSD
