| Catalog No. | Size | Price (USD) |
| 12162-T24-50 | 50 µL | $147.96 |
| 12162-T24-100 | 100 µL | $251.64 |
| 12162-T24-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-CHI3L2 Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol), IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human CHI3L2 |
| Immunogen | Recombinant Human CHI3L2 Protein (Catalog#12162-H08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human CHI3L2 (rh CHI3L2; Catalog#12162-H08H; NP_003991.2; Met1-Leu390). CHI3L2 specific IgG was purified by Human CHI3L2 affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CHIL2 Antibody; Anti-YKL-39 Antibody; Anti-YKL39 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human CHI3L2 in human kidney with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human CHI3L2 Immunohistochemistry(IHC) 30128 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining of human CHI3L2 in human kidney with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections. |
| Image 2 Alt Text | Human CHI3L2 Immunohistochemistry(IHC) 30129 |
| Image 2 URL | Source image |
Background Information
| Full Name | chitinase 3 like 2 |
| Description | Chondrocyte protein 39 (YKL-39), also known as Chitinase 3-like 2 (CHI3L2), is a secretory protein of articular chondrocytes belonging to the glycosyl hydrolase 18 family. Its highest expression is in chondrocytes, followed by synoviocytes, lung and heart. YKL-39/CHI3L2 is not detected in spleen, pancreas, and liver. YKL-39/CHI3L2 may also be expressed in developing brain and placenta. YKL-39/CHI3L2, a cartilage-related protein, is found to induce arthritis accompanied by pathologic changes in bone and cartilage. A better understanding of the immune response against cartilage-related components including YKL-39 may help to elucidate the pathological processes of arthritic disorders. Upregulation of YKL-39/CHI3L2 in osteoarthritic cartilage suggests that YKL-39/CHI3L2 may be a more accurate marker of chondrocyte activation than YKL-40, although it has yet to be established as a suitable marker in synovial fluid and serum. The decreased expression of YKL-40 by osteoarthritic chondrocytes is surprising as increased levels have been reported in rheumatoid and osteoarthritic synovial fluid, where it may derive from activated synovial cells or osteophytic tissue or by increased matrix destruction in the osteoarthritic joint. YKL-39 and YKL-40 are potentially interesting marker molecules for arthritic joint disease because they are abundantly expressed by both normal and osteoarthritic chondrocytes. |
| References |
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