| Catalog No. | Size | Price (USD) |
| 109916-R179-20 | 20 µL | $177.73 |
| 109916-R179-100 | 100 µL | $473.95 |
General Information
| Product name | Recombinant Anti-Claudin18 Antibody, Rabbit Monoclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human, Has cross-reactivity in IHC with human Claudin 18.1 and Claudin 18.2 |
| Specificity | Recognize human Claudin 18.1 and Claudin 18.2 |
| Immunogen | A synthetic peptide corresponding to the human Claudin 18 |
| Preparation | Produced in rabbits immunized with a synthetic peptide corresponding to the human Claudin 18, and purified by antigen affinity chromatography. |
| Source | Monoclonal Rabbit IgG Clone #179 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-SFTA5 Antibody; Anti-SFTPJ Antibody; Anti-UNQ778/PRO1572 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human Claudin 18 in human stomach with rabbit monoclonal antibody at 1:10000 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human Claudin18 Immunohistochemistry(IHC) 33881 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining of human Claudin 18 in human stomach with rabbit monoclonal antibody at 1:10000 dilution, formalin-fixed paraffin embedded sections. |
| Image 2 Alt Text | Human Claudin18 Immunohistochemistry(IHC) 33882 |
| Image 2 URL | Source image |
| Image 3 Description | Immunochemical staining of human Claudin 18 in human stomach with rabbit monoclonal antibody at 1:10000 dilution, formalin-fixed paraffin embedded sections. |
| Image 3 Alt Text | Human Claudin18 Immunohistochemistry(IHC) 33883 |
| Image 3 URL | Source image |
Background Information
| Full Name | claudin 18 |
| Description | Claudins family member Claudin18 (CLDN18) is a four-pass transmembrane protein with two extracellular loops and cytoplasmic N- and C-tails found in tight junctions. CLDN18 modulates paracellular permeability, polarity, and signaling. CLDN18 deficiency has been associated with atrophic gastritis, spasmolytic polypeptide-expressing metaplasia (SPEM), and asthma. Lung-specific CLDN18.1 modulates alveolar epithelial type II (AT2) cell proliferation and organ size. Restoration of CLDN18.1 expression in human lung cancer cells has been shown to suppress proliferation, inhibiting the IGF-1R/AKT axes. Not expressed in other healthy tissues, gastric mucosa-specific isoform CLDN18.2 expression manifests in primary gastric cancers. CLDN18.2 at the surface of epithelial tumor cells is a target in antibody and CAR-therapies currently in development. |
title: A transmembrane scaffold from CD20 helps recombinant expression of a chimeric claudin 18.2 in an in vitro coupled transcription and translation system.
authors: Yao Wang; Shaoting Weng; ...; Lin Wang
journal: Protein expression and purification
date: 2024-01-01
pmid: 37952787
doi: 10.1016/j.pep.2023.106392
cited_by_count: 1
techniques: Concentration Assay; Injection; Negative Control
bioz_score: 92
