| Catalog No. | Size | Price (USD) |
| 201357-T02-50 | 50 µL | $147.96 |
| 201357-T02-100 | 100 µL | $251.64 |
| 201357-T02-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-CLCN2 Antibody, Rabbit Polyclonal |
| Validated applications | ICC/IF (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human CLCN2 |
| Immunogen | E. coli-derived Human CLCN2 fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human CLCN2 fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CIC-2 Antibody; Anti-clC-2 Antibody; Anti-CLC2 Antibody; Anti-ECA2 Antibody; Anti-ECA3 Antibody; Anti-EGI11 Antibody; Anti-EGI3 Antibody; Anti-EGMA Antibody; Anti-EJM6 Antibody; Anti-EJM8 Antibody; Anti-FHA2 Antibody; Anti-FHII Antibody; Anti-HALD2 Antibody; Anti-LKPAT Antibody
Image / Experimental Information
| Image 1 Description | Immunofluorescence staining of CLCN2 in CACO2 cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS,blocked with 10% serum, and incubated with rabbit anti-Human CLCN2 polyclonal antibody (dilution ratio 1:200) at 4℃ overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue).Positive staining was localized to Cytoplasm. |
| Image 1 Alt Text | Human CLCN2 Immunofluorescence(IF) 24150 |
| Image 1 URL | Source image |
Background Information
| Description | CLCN2 encodes a voltage-gated chloride channel protein 2 (ClC-2) expressed in adrenal glomerulosa that opens at hyperpolarized membrane potentials. Channel opening depolarizes glomerulosa cells and induces expression of aldosterone synthase, the rate-limiting enzyme for aldosterone biosynthesis. Mutant channels show gain of function, with higher open probabilities at the glomerulosa resting potential. CLCN2 mutation is associated with familial hyperaldosteronism II (FH II) and CLCN2-related leukoencephalopathy (CC2L). |
| References |
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