| Catalog No. | Size | Price (USD) |
| 107328-T32-50 | 50 µL | $147.96 |
| 107328-T32-100 | 100 µL | $251.64 |
| 107328-T32-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-COMP Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol) |
| Species reactivity | Reacts with: Mouse |
| Specificity | Mouse COMP |
| Immunogen | A synthetic peptide corresponding to the center region of the Mouse COMP |
| Preparation | Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Mouse COMP, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-Comp Antibody; Anti-TSP5 Antibody
Image / Experimental Information
| Image 1 Description | Anti-COMP rabbit polyclonal antibody at 1:500 dilution Lane A: Jurkat Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:84 kDa Observed band size:94 kDa |
| Image 1 Alt Text | Mouse COMP Western blot (WB) 20528 |
| Image 1 URL | Source image |
Background Information
| Full Name | cartilage oligomeric matrix protein |
| Description | Cartilage Oligomeric Matrix Protein (COMP), also referred to as Thrombospondin-5, is a non-collagenous extracellular matrix (ECM) protein and belongs to the subgroup B of the thrombospondin protein family. This protein is expressed primarily in cartilage, ligament, and tendon, and binds to other ECM proteins such as collagen I, II and IX with high affinities depending on the divalent cations Zn2+ or Ni2+. COMP is a secreted glycoprotein that is important for growth plate organization and function. It is suggested to play a role in cell growth and development, and recent studies have revealed the possible mechanism that it protects cells against death by elevating members of the IAP (inhibitor of apoptosis protein) family of survival proteins. Mutations in COMP cause two skeletal dysplasias, pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (EDM1), and up-regulated expression of COMP are observed in rheumatoid arthritis and certain carcinomas. |
| References |
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