Anti-Contactin-1 Antibody, Rabbit Polyclonal sinobiological 10383-T60
$243.00
In stock
SKU
10383-T60
| Catalog No. | Size | Price (USD) |
| 10383-T60-100 | 100 µL | $251.64 |
General Information
| Product name | Anti-Contactin-1 Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol), ELISA (FAQ Protocol), IHC-P (FAQ Protocol), IP (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Contactin-1 |
| Immunogen | Recombinant Human Contactin-1 Protein (Catalog#10383-H08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human Contactin-1 (rh Contactin-1; Catalog#10383-H08H; NP_001834.2; Met1-Ser993). Contactin-1 specific IgG was purified by Human Contactin-1 affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CMYP12 Antibody; Anti-F3 Antibody; Anti-GP135 Antibody; Anti-MYPCN Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human Contactin-1 in human brain with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human Contactin-1 Immunohistochemistry(IHC) 40364 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining of human Contactin-1 in human brain with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Image 2 Alt Text | Human Contactin-1 Immunoprecipitation(IP) 40381 |
| Image 2 URL | Source image |
| Image 3 Description | Immunochemical staining of human Contactin-1 in human brain with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Image 3 Alt Text | Human Contactin-1 Western blot (WB) 40390 |
| Image 3 URL | Source image |
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-HD17AU1005-WB.png){kind=link}
Background Information
| Full Name | contactin 1 |
| Description | Contactins are a subgroup of molecules belonging to the immunoglobulin superfamily that are expressed exclusively in the nervous system. The subgroup consists of six members: Contactin-1, Contactin-2 (TAG-1), Contactin-3 (BIG-1), BIG-2, Contactin-5 (NB-2) and NB-3. Since their identification in the late 1980s, Contactin-1 and Contactin-2 have been studied extensively. Axonal expression and the neurite extension activity of Contactin-1 and Contactin-2 attracted researchers to study the function of these molecules in axon guidance during development. Contactin-1 and Contactin-2 have come to be known as the principal molecules in the function and maintenance of myelinated neurons. In contrast, the function of the other four members of this subgroup remained unknown until recently. Contactin-1 is a cell surface adhesion molecule that is normally expressed by neurons and oligodendrocytes. Particularly high levels of Contactin-1 are present during brain development. Contactin-1 and Contactin-2 are differentially expressed in a number of neuronal tissues during development, and they interact with several ligands including Nr-CAM, L1, NCAM, neurocan, phosphacan, and tenascin. As a cell adhesion molecule, Contactin-1 plays a role in the formation of axon connections in the developing nervous system. It was demonstrated that Contactin-1 participates in signal pathways via its association with Contactin-associated protein (CNTNAP1), receptor protein tyrosine phosphatase beta (RPTPb) and NOTCH1. Contactin-1 is also involved in paranodal axo-glial junction formation and oligodendrocytes generation. Furthermore, studies indicated that Contactin-1 functions importantly in the invasion and metastasis of lung adenocarcinoma cells. Contactin-1 may also significantly influence the functional expression and distribution of Na channels in neurons. |
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