| Catalog No. | Size | Price (USD) |
| 40143-MM05TA-20 | 20 µL | $118.49 |
| 40143-MM05TA-50 | 50 µL | $222.17 |
| 40143-MM05TA-100 | 100 µL | $370.28 |
General Information
| Product name | SARS-CoV / SARS-CoV-2 Nucleocapsid Antibody, Chimeric MAb |
| Validated applications | WB (FAQ Protocol), ELISA (FAQ Protocol), IHC-P (FAQ Protocol), FCM (FAQ Protocol), ICC/IF (FAQ Protocol) |
| Application notes | (Antibody's applications have not been validated with corresponding viruses. Optimal concentrations/dilutions should be determined by the end user.) |
| Specificity | SARS-CoV Nucleocapsid Has cross-reactivity in ELISA with SARS-CoV-2 Omicron (B.1.1.529) Nucleocapsid Protein (Cat #40588-V07E34) SARS-CoV-2 Omicron (BA.2) Nucleocapsid Protein (Cat# 40588-V07E35) SARS-CoV-2 Omicron XE(BA.1 x BA.2) Nucleocapsid Protein (Cat# 40588-V07E36) SARS-CoV-2 Omicron (BA.4) Nucleocapsid Protein (Cat# 40588-V07E37) SARS-CoV-2 Delta (B.1.617.2) Nucleocapsid Protein (Cat# 40588-V07E29) SARS-CoV-2 Nucleocapsid Protein (Cat# 40588-V08B) No cross-reactivity in ELISA with MERS-CoV Nucleocapsid protein (Cat# 40068-V08B) HCoV-229E Nucleocapsid protein (Cat# 40640-V07E) HCoV-NL63 Nucleocapsid protein (Cat# 40641-V07E) HCoV-HKU1(isolate N5) Nucleocapsid protein (Cat# 40642-V07E) HCoV-OC43 Nucleocapsid protein (Cat# 40643-V07E) |
| Immunogen | Recombinant SARS-CoV Nucleoprotein / NP Protein (Catalog#40143-V08B) |
| Preparation | It is a chimeric monoclonal antibody combining the constant domains of the human IgG1 molecule with mouse variable regions, and the variable region was from mouse monoclonal antibody (Cat#40143-MM05). The chimeric monoclonal antibody was produced using recombinant antibody technology. |
| Source | Monoclonal Mouse (variable region) / human (kappa / IgG1 constant) chimeric antibody Clone #05 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Image / Experimental Information
| Image 1 Description | Flow cytometric analysis of SARS-COV-2 Nucleocapsid overexpressed HEK293 cells.Cells were stained with purified anti-SARS-COV-2 Nucleocapsid Chimeric MAb, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. (Validation Experiment) |
| Image 1 Alt Text | SARS Coronavirus Nucleocapsid Flow Cytometry (FC) 32527 |
| Image 1 URL | Source image |
| Image 2 Description | Flow cytometric analysis of SARS-COV-2 Nucleocapsid overexpressed HEK293 cells.Cells were stained with purified anti-SARS-COV-2 Nucleocapsid Chimeric MAb, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. (Validation Experiment) |
| Image 2 Alt Text | SARS Coronavirus Nucleocapsid Western blot (WB) 32567 |
| Image 2 URL | Source image |
| Image 3 Description | Flow cytometric analysis of SARS-COV-2 Nucleocapsid overexpressed HEK293 cells.Cells were stained with purified anti-SARS-COV-2 Nucleocapsid Chimeric MAb, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. (Validation Experiment) |
| Image 3 Alt Text | SARS Coronavirus Nucleocapsid Immunohistochemistry(IHC) 32664 |
| Image 3 URL | Source image |
| Image 4 Description | Flow cytometric analysis of SARS-COV-2 Nucleocapsid overexpressed HEK293 cells.Cells were stained with purified anti-SARS-COV-2 Nucleocapsid Chimeric MAb, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. (Validation Experiment) |
| Image 4 Alt Text | SARS Coronavirus Nucleocapsid Immunofluorescence(IF) 32688 |
| Image 4 URL | Source image |
Background Information
| Description | Coronaviruses are enveloped viruses with a positive-sense RNA genome and with a nucleocapsid of helical symmetry. Coronavirus nucleoproteins localize to the cytoplasm and the nucleolus, a subnuclear structure, in both virus-infected primary cells and in cells transfected with plasmids that express N protein. The coronavirus N protein is required for coronavirus RNA synthesis and has RNA chaperone activity that may be involved in template switch. Nucleocapsid protein is the most abundant protein of coronavirus. During virion assembly, N protein binds to viral RNA and leads to the formation of the helical nucleocapsid. Nucleocapsid protein is a highly immunogenic phosphoprotein also implicated in viral genome replication and in modulating cell signaling pathways. Because of the conservation of the N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool. |
| References |
|
[{"title":"SARS-CoV-2 Omicron BA.2.86 and JN.1 expand tropism in human proximal intestinal epithelium.","authors":["Kenrie Py Hui","John Cw Ho","...","Michael Cw Chan"],"journal":"Nature Communications","date":"2026-06-05","pmid":"42248900","doi":"10.1038/s41467-026-74111-y"},{"title":"4-Octyl itaconate blocks STAT3-induced ACE2 expression to reduce uptake of SARS-CoV-2.","authors":["Hauke J Weiss","Alexander Hooftman","...","Luke A J O'Neill"],"journal":"Biochemical pharmacology","date":"2026-04-25","pmid":"42044812","doi":"10.1016/j.bcp.2026.118007"},{"title":"Peptide with neutralizing activity against severe acute respiratory syndrome coronavirus 2","authors":["Yong Ji Chung","Eun Mi Kim","...","Min Kyeong Jeong"],"journal":"","date":"2026-03-31","pmid":"","doi":""},{"title":"HLA-C–derived peptide MH-1 as an early-stage intervention against SARS-CoV-2 infection","authors":["Ting-Yan Jian","Sheng-Yu Huang","...","Shin-Ru Shih"],"journal":"Molecular Medicine","date":"2026-02-16","pmid":"41699454","doi":"10.1186/s10020-026-01434-3"},{"title":"Intranasal S-2P and lentinan formulation confers broad protection against SARS-CoV-2 VOCs via IFN-γ-dominant mechanisms.","authors":["Zhendong Pan","Xu Zheng","...","Ping Zhao"],"journal":"NPJ vaccines","date":"2026-01-30","pmid":"41611712","doi":""},{"title":"Host-Directed Antiviral Activity of SB2960 Through Selective Induction and Remodeling of Stress Granules.","authors":["Wan Gi Byun","Sumin Son","...","Seung Bum Park"],"journal":"Advanced science (Weinheim, Baden-Wurttemberg, Germany)","date":"2026-01-14","pmid":"41532664","doi":""},{"title":"Taguchi optimization of CPTES chemistry for photonic crystal-based biosensors: detection of Anti-SARS-CoV-2 antibodies in human serum","authors":[],"journal":"Sensors and Actuators B: Chemical","date":"2025-10-01","pmid":"","doi":"10.1016/j.snb.2025.138979"},{"title":"SARS-CoV-2 infection induces ZBP1-dependent PANoptosis in bystander cells","authors":["Bo Yang","Ao Hu","...","Kai Deng"],"journal":"Proceedings of the National Academy of Sciences of the United States of America","date":"2025-07-08","pmid":"40627395","doi":""},{"title":"Targeting heptad repeats and fusion peptide: nanoparticle vaccine elicits mucosal immune response against SARS-CoV-2 variants","authors":["Chaofeng Liang","Rong Li","...","Yiwen Zhang"],"journal":"Journal of Nanobiotechnology","date":"2025-07-03","pmid":"","doi":"10.1186/s12951-025-03582-w"},{"title":"Lipid Nanoparticle Development for A Fluvid mRNA Vaccine Targeting Seasonal Influenza and SARS-CoV-2.","authors":["Jiin Felgner","Jenny E Hernandez-Davies","...","Li Liang"],"journal":"NPJ vaccines","date":"2025-06-11","pmid":"40500288","doi":"10.1038/s41541-025-01153-6"},{"title":"Single-particle quantification of SARS-CoV-2 virus-like particles using flow virometry.","authors":["Hyeop Jin","Ye Rae Cho","Yong Tae Jung"],"journal":"Archives of Virology","date":"2025-06-07","pmid":"40483334","doi":"10.1007/s00705-025-06339-w"},{"title":"Somatic hypermutation shapes the viral escape profile of SARS-CoV-2 neutralising antibodies","authors":["Matthias Bruhn","Maureen Obara","...","Ulrich Kalinke"],"journal":"EBioMedicine","date":"2025-06-01","pmid":"40403696","doi":"10.1016/j.ebiom.2025.105770"},{"title":"Dynamic Interaction Between SARS-CoV-2 and Influenza A Virus Infection in Human Respiratory Tissues and Cells.","authors":["John C W Ho","Kachun Ng","...","Kenrie P Y Hui"],"journal":"Microorganisms","date":"2025-04-25","pmid":"40431161","doi":"10.3390/microorganisms13050988"},{"title":"TCM theory-inspired discovery of DNJ-flavonoid conjugates as broad-spectrum anti-SARS-CoV-2 agents by primarily targeting ER-associated glycoprotein folding process.","authors":["Yan-Yun Liu","Zheng-Ao Li","...","Xu Deng"],"journal":"European Journal of Medicinal Chemistry","date":"2025-04-12","pmid":"40168909","doi":"10.1016/j.ejmech.2025.117582"},{"title":"Complement is primarily activated in the lung in a mouse model of severe COVID-19","authors":["Peter J. Szachowicz","Christine Wohlford-Lenane","...","Paul B. McCray"],"journal":"iScience","date":"2025-02-01","pmid":"40034849","doi":"10.1016/j.isci.2025.111930"},{"title":"High resistance barrier and prophylactic protection in preclinical models of SARS-CoV-2 with two siRNA combination","authors":["Yesseinia I Anglero-Rodriguez","Florian A Lempp","...","Vasant Jadhav"],"journal":"Nucleic Acids Research","date":"2025-01-13","pmid":"39657790","doi":"10.1093/nar/gkae1195"},{"title":"Investigating the roles of microglia in viral CNS disease","authors":["Pachow, Collin "],"journal":"","date":"2025-01-01","pmid":"","doi":""},{"title":"A human monoclonal antibody neutralizing SARS-CoV-2 Omicron variants containing the L452R mutation","authors":["Saskia C. Stein","Guido Hansen","...","Stacey Schultz-Cherry"],"journal":"Journal of virology","date":"2024-12-01","pmid":"39494911","doi":""},{"title":"Elimination of olfactory sensory neurons by zinc sulfate inoculation prevents SARS-CoV-2 infection of the brain in K18-hACE2 transgenic mice","authors":["Ji-Hun Lee","Eun-Seon Yoo","...","Yang-Kyu Choi"],"journal":"Scientific Reports","date":"2024-11-13","pmid":"39537718","doi":"10.1038/s41598-024-78538-5"},{"title":"The lethal K18-hACE2 knock-in mouse model mimicking the severe pneumonia of COVID-19 is practicable for antiviral development.","authors":["Zhen Zhang","Li Zhou","...","Yu Chen"],"journal":"Emerging microbes & infections","date":"2024-05-26","pmid":"38753462","doi":""},{"title":"Early, rapidly progressive vasculopathy in a transplanted heart: a possible complication of COVID-19.","authors":["Bryan G Pearson","David H Walker","...","Paul J Boor"],"journal":"Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology","date":"2024-05-25","pmid":"38801983","doi":"10.1016/j.carpath.2024.107661"},{"title":"Development of a mutant aerosolized ACE2 that neutralizes SARS-CoV-2 in vivo .","authors":["Daniel L Kober","Marley C Caballero Van Dyke","...","John W Schoggins"],"journal":"mBio","date":"2024-05-21","pmid":"38771062","doi":"10.1128/mbio.00768-24"},{"title":"Discovery of meisoindigo derivatives as noncovalent and orally available M pro inhibitors: their therapeutic implications in the treatment of COVID-19.","authors":["Qingtian Gao","Sixu Liu","...","Xu Deng"],"journal":"European Journal of Medicinal Chemistry","date":"2024-05-16","pmid":"38762916","doi":"10.1016/j.ejmech.2024.116498"},{"title":"Ciclopirox inhibits SARS-CoV-2 replication by promoting the degradation of the nucleocapsid protein","authors":["Xiafei Wei","Yuzheng Zhou","...","Zheng Zhang"],"journal":"Acta Pharmaceutica Sinica. B","date":"2024-03-12","pmid":"","doi":"10.1016/j.apsb.2024.03.009"},{"title":"A mouse xenograft long-term replication yields a SARS-CoV-2 Delta mutant with increased lethality.","authors":["Dongbum Kim","Minyoung Kim","...","Hyung-Joo Kwon"],"journal":"Journal of medical virology","date":"2024-02-14","pmid":"38345153","doi":"10.1002/jmv.29459"},{"title":"The Abundant Distribution and Duplication of SARS-CoV-2 in the Cerebrum and Lungs Promote a High Mortality Rate in Transgenic hACE2-C57 Mice.","authors":["Heng Li","Xin Zhao","...","Longding Liu"],"journal":"International Journal of Molecular Sciences","date":"2024-01-24","pmid":"38256071","doi":"10.3390/ijms25020997"},{"title":"A stapled lipopeptide platform for preventing and treating highly pathogenic viruses of pandemic potential.","authors":["Gregory H Bird","J J Patten","...","Loren D Walensky"],"journal":"Nature Communications","date":"2024-01-08","pmid":"38177138","doi":"10.1038/s41467-023-44361-1"},{"title":"IFN-γ-mediated control of SARS-CoV-2 infection through nitric oxide.","authors":["Bruno J de Andrade Silva","Paul A Krogstad","...","Robert L Modlin"],"journal":"Frontiers in Immunology","date":"2024-01-03","pmid":"38162653","doi":"10.3389/fimmu.2023.1284148"},{"title":"SARS-CoV-2 in Animal Companions: A Serosurvey in Three Regions of Southern Italy.","authors":["Angelica Bianco","Alessio Bortolami","...","Antonio Parisi"],"journal":"Life (Basel, Switzerland)","date":"2023-12-16","pmid":"38137955","doi":"10.3390/life13122354"},{"title":"Study of the Immunogenicity of Combination of Recombinant RBD (Omicron) and Nucleocapsid Proteins of SARS-CoV-2 Expressed in Pichia Pastoris","authors":["Shakhnoz Azimova","Sobirdjan Sasmakov","...","Aygul Yarilkaganova"],"journal":"The Open Biochemistry Journal","date":"2023-11-30","pmid":"","doi":"10.2174/011874091x273716231122102205"},{"title":"A Mosaic Nanoparticle Vaccine Elicits Potent Mucosal Immune Response with Significant Cross‐Protection Activity against Multiple SARS‐CoV‐2 Sublineages","authors":["Xiantao Zhang","Shijian Wu","...","Hui Zhang"],"journal":"Advanced Science","date":"2023-08-01","pmid":"37526323","doi":"10.1002/advs.202301034"},{"title":"SARS-Cov-2 infection and neuropathological findings: a report of 18 cases and review of the literature.","authors":["Laetitia Lebrun","Lara Absil","...","Isabelle Salmon"],"journal":"Acta Neuropathologica Communications","date":"2023-05-12","pmid":"37165453","doi":""},{"title":"Importance of ACE2 for SARS-CoV-2 Infection of Kidney Cells.","authors":["Marie-Kristin Kroll","Sebastian Schloer","...","Giuliano Ciarimboli"],"journal":"Biomolecules","date":"2023-04-01","pmid":"36979408","doi":""},{"title":"Improved Recovery of Captured Airborne Bacteria and Viruses with Liquid-Coated Air Filters","authors":["Daniel P. Regan","ChunKi Fong","...","Caitlin Howell"],"journal":"ACS Applied Materials & Interfaces","date":"2023-03-21","pmid":"36331290","doi":"10.1021/acsami.2c14754"},{"title":"Characterization of a Vesicular Stomatitis Virus-Vectored Recombinant Virus Bearing Spike Protein of SARS-CoV-2 Delta Variant","authors":["Wenwen He","Huan Cui","...","Linda Houhamdi"],"journal":"Microorganisms","date":"2023-02-08","pmid":"36838396","doi":"10.3390/microorganisms11020431"},{"title":"Drug repurposing screening validated by experimental assays identifies two clinical drugs targeting SARS-CoV-2 main protease","authors":["Denis N. Prada Gori","Santiago Ruatta","...","Alan Talevi"],"journal":"Frontiers in Drug Discovery","date":"2023-01-05","pmid":"","doi":"10.3389/fddsv.2022.1082065"},{"title":"Rapid quantitation of SARS-CoV-2 antibodies in clinical samples with an electrochemical sensor","authors":["Sanjay S. Timilsina","Nolan Durr","...","Donald E. Ingber"],"journal":"Biosensors & bioelectronics","date":"2022-12-24","pmid":"","doi":"10.1016/j.bios.2022.115037"},{"title":"Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages","authors":["Katja Hönzke","Benedikt Obermayer","...","Andreas C. Hocke"],"journal":"The European Respiratory Journal","date":"2022-12-01","pmid":"35728978","doi":"10.1183/13993003.02725-2021"},{"title":"Rapid quantitative electrochemical detection of SARS-CoV-2 antibodies in plasma and dried blood spot samples","authors":["Timilsina Sanjay S.","Durr Nolan","...","Ingber Donald E."],"journal":"medRxiv","date":"2022-10-17","pmid":"","doi":"10.1101/2022.10.16.22281144"},{"title":"A recombinant subunit vaccine candidate produced in plants elicits neutralizing antibodies against SARS-CoV-2 variants in macaques","authors":["Narach Khorattanakulchai","Kanjana Srisutthisamphan","...","Waranyoo Phoolcharoen"],"journal":"Frontiers in Plant Science","date":"2022-09-28","pmid":"","doi":"10.3389/fpls.2022.901978"},{"title":"Stenoparib, an inhibitor of cellular poly (ADP-ribose) polymerases (PARPs), blocks in vitro replication of SARS-CoV-2 variants.","authors":["Katherine E Zarn","Sierra A Jaramillo","...","Christopher T French"],"journal":"PLoS ONE","date":"2022-09-16","pmid":"36103462","doi":"10.1371/journal.pone.0272916"},{"title":"USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STING","authors":["Rebekka Karlowitz","Megan L. Stanifer","...","Sjoerd J. L. van Wijk"],"journal":"Cell death & disease","date":"2022-08-06","pmid":"","doi":"10.1038/s41419-022-05124-w"},{"title":"Lower SARS-CoV-2 Seroprevalence among Cancer Patients in Sub-Saharan Africa","authors":["For Yue Tso","Salum J. Lidenge","...","Robert Flisiak"],"journal":"Journal of Clinical Medicine","date":"2022-07-29","pmid":"35956046","doi":"10.3390/jcm11154428"},{"title":"Histologic pulmonary lesions of SARS-CoV-2 in 4 nonhuman primate species: An institutional comparative review.","authors":["Chad S Clancy","Carl Shaia","...","Dana Scott"],"journal":"Veterinary pathology","date":"2022-07-01","pmid":"34963391","doi":"10.1177/03009858211067468"},{"title":"Spatially Patterned Neutralizing Icosahedral DNA Nanocage for Efficient SARS-CoV-2 Blocking","authors":["Jialu Zhang","Yunyun Xu","...","Yanling Song"],"journal":"Journal of the American Chemical Society","date":"2022-06-30","pmid":"pm35770902","doi":""},{"title":"SARS-CoV-2 Omicron variant causes mild pathology in the upper and lower respiratory tract of hamsters","authors":["Federico Armando","Georg Beythien","...","Wolfgang Baumgärtner"],"journal":"Nature Communications","date":"2022-06-20","pmid":"35725735","doi":"10.1038/s41467-022-31200-y"},{"title":"Melatonin drugs inhibit SARS-CoV-2 entry into the brain and virus-induced damage of cerebral small vessels","authors":["Erika Cecon","Daniela Fernandois","...","Ralf Jockers"],"journal":"Cellular and Molecular Life Sciences","date":"2022-06-13","pmid":"35697820","doi":"10.1007/s00018-022-04390-3"},{"title":"Receptor binding domain proteins of SARS‐CoV‐2 variants produced in Nicotiana benthamiana elicit neutralizing antibodies against variants of concern","authors":["Narach Khorattanakulchai","Suwimon Manopwisedjaroen","...","Waranyoo Phoolcharoen"],"journal":"Journal of medical virology","date":"2022-06-01","pmid":"35615895","doi":"10.1002/jmv.27881"},{"title":"Non-invasive administration of AAV to target lung parenchymal cells and develop SARS-CoV-2-susceptible mice.","authors":["Myeon-Sik Yang","Min-Jung Park","...","Bumseok Kim"],"journal":"Molecular therapy : the journal of the American Society of Gene Therapy","date":"2022-05-09","pmid":"35007757","doi":""},{"title":"Smartphone-based sensitive detection of SARS-CoV-2 from saline gargle samples via flow profile analysis on a paper microfluidic chip.","authors":["Patarajarin Akarapipad","Kattika Kaarj","...","Jeong-Yeol Yoon"],"journal":"Biosensors & bioelectronics","date":"2022-04-28","pmid":"35334331","doi":""},{"title":"An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern","authors":["Wenjuan Du","Daniel L. Hurdiss","...","Berend-Jan Bosch"],"journal":"Science immunology","date":"2022-04-26","pmid":"35471062","doi":"10.1126/sciimmunol.abp9312"},{"title":"Pulmonary fibrosis in a dog as a sequela of infection with Severe Acute Respiratory Syndrome Coronavirus 2? A case report","authors":["Barbara Colitti","Luca Manassero","...","Sergio Rosati"],"journal":"BMC Veterinary Research","date":"2022-03-22","pmid":"35317791","doi":"10.1186/s12917-022-03191-x"},{"title":"Robust and durable prophylactic protection conferred by RNA interference in preclinical models of SARS-CoV-2","authors":["Anglero-Rodriguez Yesseinia I.","Lempp Florian A.","...","Jadhav Vasant"],"journal":"bioRxiv","date":"2022-03-21","pmid":"","doi":"10.1101/2022.03.20.485044"},{"title":"Evolution of pathological findings in surveillance biopsies of lung transplant recipients infected with SARS‐CoV‐2","authors":["Alexander N. Wein","Jing Liu","Chieh‐Yu Lin"],"journal":"Transplant Infectious Disease","date":"2022-03-21","pmid":"35279033","doi":"10.1111/tid.13823"},{"title":"A novel intranasal administration adenoviral vector-based platform for rapid COVID-19 vaccine development","authors":["Yuan Yifei","Gao Xing","...","Liang Min"],"journal":"bioRxiv","date":"2022-02-22","pmid":"","doi":"10.1101/2022.02.21.481247"},{"title":"An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants","authors":["Du Wenjuan","Hurdiss Daniel L.","...","Bosch Berend-Jan"],"journal":"bioRxiv","date":"2022-02-17","pmid":"","doi":"10.1101/2022.02.17.480751"},{"title":"Imatinib and methazolamide ameliorate COVID-19-induced metabolic complications via elevating ACE2 enzymatic activity and inhibiting viral entry","authors":["Zilun Li","Meixiu Peng","...","Sifan Chen"],"journal":"Cell metabolism","date":"2022-02-11","pmid":"35150639","doi":"10.1016/j.cmet.2022.01.008"},{"title":"SARS-CoV-2 Omicron variant causes mild pathology in the upper and lower respiratory tract of Syrian golden hamsters (Mesocricetus auratus)","authors":["Federico Armando","Georg Beythien","...","Wolfgang Baumgärtner"],"journal":"Europe PMC","date":"2022-02-01","pmid":"","doi":"10.21203/rs.3.rs-1315280"},{"title":"Detection of anti-SARS-CoV-2 antibody for the diagnosis of past-COVID-19 infection cases using a liquid-crystal-based immunosensor","authors":["Dong Yoon Jeon","Chang-Hyun Jang"],"journal":"Liquid Crystals","date":"2022-01-27","pmid":"","doi":"10.1080/02678292.2022.2028315"},{"title":"The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in non-human primates and has an extended half-life in humans","authors":["Yueh-Ming Loo","Patrick M. McTamney","...","Mark T. Esser"],"journal":"Science translational medicine","date":"2022-01-25","pmid":"35076282","doi":"10.1126/scitranslmed.abl8124"},{"title":"The MEK1/2-inhibitor ATR-002 efficiently blocks SARS-CoV-2 propagation and alleviates pro-inflammatory cytokine/chemokine responses","authors":["André Schreiber","Dorothee Viemann","...","Stephan Ludwig"],"journal":"Cellular and Molecular Life Sciences","date":"2022-01-10","pmid":"35013790","doi":"10.1007/s00018-021-04085-1"},{"title":"EVALUATING THE FUNCTIONAL CONTRIBUTIONS OF MICROGLIA IN HOST DEFENSE AND DISEASE IN A MODEL OF MOUSE CORONAVIRUS-INDUCED NEUROLOGIC DISAESE","authors":["Cheng, Yuting "],"journal":"","date":"2022-01-01","pmid":"","doi":""},{"title":"Divergent SARS CoV-2 Omicron-specific T- and B-cell responses in COVID-19 vaccine recipients","authors":["GeurtsvanKessel Corine H.","Geers Daryl","...","de Vries Rory D."],"journal":"medRxiv","date":"2021-12-29","pmid":"","doi":"10.1101/2021.12.27.21268416"},{"title":"Coronavirus iRNA compositions and methods of use thereof","authors":["Akin Akinc","James D. McIninch","...","Florian A. Lempp"],"journal":"","date":"2021-12-28","pmid":"","doi":""},{"title":"Microglia Do Not Restrict SARS-CoV-2 Replication following Infection of the Central Nervous System of K18-Human ACE2 Transgenic Mice","authors":["Gema M. Olivarria","Yuting Cheng","...","Tom Gallagher"],"journal":"Journal of virology","date":"2021-12-22","pmid":"34935438","doi":"10.1128/jvi.01969-21"},{"title":"Maternal SARS-CoV-2 infection elicits sexually dimorphic placental immune responses","authors":["Evan A. Bordt","Lydia L. Shook","...","Andrea G. Edlow"],"journal":"Science translational medicine","date":"2021-12-09","pmid":"34664987","doi":"10.1126/scitranslmed.abi7428"},{"title":"Spherical Neutralizing Aptamer Inhibits SARS-CoV-2 Infection and Suppresses Mutational Escape","authors":["Miao Sun","Siwen Liu","...","Chaoyong Yang"],"journal":"Journal of the American Chemical Society","date":"2021-12-02","pmid":"pm34855379","doi":""},{"title":"Microglia do not restrict SARS-CoV-2 replication following infection of the central nervous system of K18-hACE2 transgenic mice","authors":["Gema M. Olivarria","Yuting Cheng","...","Thomas E. Lane"],"journal":"bioRxiv","date":"2021-11-17","pmid":"34816260","doi":"10.1101/2021.11.15.468761"},{"title":"Broad Spectrum Antiviral Properties of Cardiotonic Steroids Used as Potential Therapeutics for Emerging Coronavirus Infections","authors":["Young-Hee Jin","Sangeun Jeon","...","Maria Rosaria Lauro"],"journal":"Pharmaceutics","date":"2021-11-02","pmid":"34834252","doi":"10.3390/pharmaceutics13111839"},{"title":"Significantly reduced abilities to cross-neutralize SARS-CoV-2 variants by sera from convalescent COVID-19 patients infected by Delta or early strains","authors":["Ting Pan","Zhongwei Hu","...","Hui Zhang"],"journal":"Cellular & molecular immunology","date":"2021-10-11","pmid":"34635805","doi":"10.1038/s41423-021-00776-8"},{"title":"Gold nanoparticle based plasmonic sensing for the detection of SARS-CoV-2 nucleocapsid proteins","authors":["Kamyar Behrouzi","Liwei Lin"],"journal":"Biosensors & bioelectronics","date":"2021-09-28","pmid":"34607117","doi":"10.1016/j.bios.2021.113669"},{"title":"Immunogenicity Studies of Plant-Produced SARS-CoV-2 Receptor Binding Domain-Based Subunit Vaccine Candidate with Different Adjuvant Formulations","authors":["Konlavat Siriwattananon","Suwimon Manopwisedjaroen","...","Sergio Rosales-Mendoza"],"journal":"Vaccines","date":"2021-07-05","pmid":"34358160","doi":"10.3390/vaccines9070744"},{"title":"Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell","authors":["Maritza Puray-Chavez","Kyle M. LaPak","...","Sebla B. Kutluay"],"journal":"Cell Reports","date":"2021-06-23","pmid":"34214467","doi":"10.1016/j.celrep.2021.109364"},{"title":"Multiplexed Serum Antibody Screening Platform Using Virus Extracts from Endemic Coronaviridae and SARS-CoV-2.","authors":["Simon Fink","Felix Ruoff","...","Markus F Templin"],"journal":"ACS Infectious Diseases","date":"2021-06-23","pmid":"33724771","doi":"10.1021/acsinfecdis.0c00725"},{"title":"Plant-Produced Receptor-Binding Domain of SARS-CoV-2 Elicits Potent Neutralizing Responses in Mice and Non-human Primates","authors":["Konlavat Siriwattananon","Suwimon Manopwisedjaroen","...","Waranyoo Phoolcharoen"],"journal":"Frontiers in Plant Science","date":"2021-05-13","pmid":"34054909","doi":"10.3389/fpls.2021.682953"},{"title":"Self-Assembling Nanoparticle Vaccines Displaying the Receptor Binding Domain of SARS-CoV-2 Elicit Robust Protective Immune Responses in Rhesus Monkeys","authors":["Heng Li","Lei Guo","...","Longding Liu"],"journal":"Bioconjugate Chemistry","date":"2021-05-06","pmid":"","doi":"10.1021/acs.bioconjchem.1c00208"},{"title":"Safety and immunogenicity of SARS-CoV-2 recombinant protein vaccine formulations in healthy adults: interim results of a randomised, placebo-controlled, phase 1–2, dose-ranging study","authors":["Paul A Goepfert","Bo Fu","...","Guy de Bruyn"],"journal":"The Lancet. 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