| Catalog No. | Size | Price (USD) |
| 40143-R001-20 | 20 µL | $118.49 |
| 40143-R001-50 | 50 µL | $222.17 |
| 40143-R001-100 | 100 µL | $370.28 |
General Information
| Product name | SARS-CoV/SARS-CoV-2 Nucleocapsid Antibody, Rabbit MAb |
| Validated applications | WB (FAQ Protocol), ELISA (FAQ Protocol), IHC-P (FAQ Protocol), ICC/IF (FAQ Protocol) |
| Application notes | (Antibody's applications have not been validated with corresponding viruses. Optimal concentrations/dilutions should be determined by the end user.) |
| Specificity | SARS-CoV Nucleocapsid Has cross-reactivity in ELISA and WB with SARS-CoV-2 Nucleocapsid Protein (Cat# 40588-V08B) Has cross-reactivity in ELISA with SARS-CoV-2 Omicron (B.1.1.529) Nucleocapsid Protein (Cat #40588-V07E34) SARS-CoV-2 Omicron (BA.2) Nucleocapsid Protein (Cat# 40588-V07E35) SARS-CoV-2 Omicron XE(BA.1 x BA.2) Nucleocapsid Protein (Cat# 40588-V07E36) SARS-CoV-2 Omicron (BA.4) Nucleocapsid Protein (Cat# 40588-V07E37) SARS-CoV-2 Delta (B.1.617) Nucleocapsid (D377Y) Protein (Cat# 40588-V07E16) SARS-CoV-2 Delta (B.1.617) Nucleocapsid (R203M, D377Y) Protein (Cat# 40588-V07E20) SARS-CoV-2 Delta (B.1.617.2) Nucleocapsid Protein (Cat# 40588-V07E29) SARS-CoV-2 Delta (B.1.617.3) Nucleocapsid (P67S, R203M, D377Y) Protein (Cat# 40588-V07E30) SARS-CoV-2 Alpha (B.1.1.7) Nucleocapsid(R203K, G204R) Protein (Cat# 40588-V07E1) SARS-CoV-2 Alpha (B.1.1.7) Nucleocapsid(I292T) Protein (Cat# 40588-V07E4) SARS-CoV-2 Alpha (B.1.1.7) Nucleocapsid(D3L, R203K, G204R, S235F) Protein (Cat# 40588-V07E7) SARS-CoV-2 Alpha (B.1.1.7) Nucleocapsid(D3L, S235F) Protein (Cat# 40588-V07E8) SARS-CoV-2 Alpha(B.1.1.7/ B.1.237) Nucleocapsid(S194L) Protein (Cat# 40588-V07E3) SARS-CoV-2 Alpha/beta(B.1.1.7/ B.1.351/ A.2.2) Nucleocapsid(P13L) Protein (Cat# 40588-V07E2) SARS-CoV-2 Beta(B.1.351/B.1.351.2/b.1.351.3/B.1.427/B.1.429) Nucleocapsid (T205I) Protein (Cat# 40588-V07E9) SARS-CoV-2 Gamma(P.1/ P.1.1/ P.1.2) Nucleocapsid (P80R) Protein (Cat# 40588-V07E11) SARS-CoV-2 Eta(B.1.525) Nucleocapsid (A12G, T205I) Protein (Cat# 40588-V07E19) SARS-CoV-2 Nucleocapsid Protein (Cat# 40588-V07E) No cross-reactivity in ELISA with MERS-CoV Nucleocapsid protein (Cat# 40068-V08B) HCoV-229E Nucleocapsid protein (Cat# 40640-V07E) HCoV-NL63 Nucleocapsid protein (Cat# 40641-V07E) HCoV-HKU1(isolate N5) Nucleocapsid protein (Cat# 40642-V07E) HCoV-OC43 Nucleocapsid protein (Cat# 40643-V07E) |
| Immunogen | Recombinant SARS-CoV Nucleoprotein / NP Protein (Catalog#40143-V08B) |
| Preparation | This product is a recombinant monoclonal antibody expressed from HEK293 cells. |
| Source | Monoclonal Rabbit IgG Clone #001 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Image / Experimental Information
| Image 1 Description | Anti-SARS-NP rabbit monoclonal antibody at 1:2000 dilution. Lane A: SARS-CoV NP Protein (Cat#40143-V08B) (30ng) Lane B: SARS-CoV NP Protein (Cat#40143-V08B) (5ng) Lane C: SARS-CoV-2 (2019-nCoV) NP Protein (Cat#40588-V08B) (30ng) Lane D: SARS-CoV-2 (2019-nCoV) NP Protein (Cat#40588-V08B) (5ng) Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. |
| Image 1 Alt Text | SARS CoV Nucleocapsid Western blot (WB) 29814 |
| Image 1 URL | Source image |
| Image 2 Description | Anti-SARS-NP rabbit monoclonal antibody at 1:2000 dilution. Lane A: SARS-CoV NP Protein (Cat#40143-V08B) (30ng) Lane B: SARS-CoV NP Protein (Cat#40143-V08B) (5ng) Lane C: SARS-CoV-2 (2019-nCoV) NP Protein (Cat#40588-V08B) (30ng) Lane D: SARS-CoV-2 (2019-nCoV) NP Protein (Cat#40588-V08B) (5ng) Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. |
| Image 2 Alt Text | SARS Coronavirus Nucleocapsid Immunohistochemistry(IHC) 32673 |
| Image 2 URL | Source image |
| Image 3 Description | Anti-SARS-NP rabbit monoclonal antibody at 1:2000 dilution. Lane A: SARS-CoV NP Protein (Cat#40143-V08B) (30ng) Lane B: SARS-CoV NP Protein (Cat#40143-V08B) (5ng) Lane C: SARS-CoV-2 (2019-nCoV) NP Protein (Cat#40588-V08B) (30ng) Lane D: SARS-CoV-2 (2019-nCoV) NP Protein (Cat#40588-V08B) (5ng) Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. |
| Image 3 Alt Text | SARS Coronavirus Nucleocapsid Immunofluorescence(IF) 32695 |
| Image 3 URL | Source image |
Background Information
| Description | Coronaviruses are enveloped viruses with a positive-sense RNA genome and with a nucleocapsid of helical symmetry. Coronavirus nucleoproteins localize to the cytoplasm and the nucleolus, a subnuclear structure, in both virus-infected primary cells and in cells transfected with plasmids that express N protein. The coronavirus N protein is required for coronavirus RNA synthesis and has RNA chaperone activity that may be involved in template switch. Nucleocapsid protein is the most abundant protein of coronavirus. During virion assembly, N protein binds to viral RNA and leads to the formation of the helical nucleocapsid. Nucleocapsid protein is a highly immunogenic phosphoprotein also implicated in viral genome replication and in modulating cell signaling pathways. Because of the conservation of the N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool. |
| References |
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Faucher","...","Matthew Bogyo"],"journal":"Journal of the American Chemical Society","date":"2025-02-24","pmid":"pm39993812","doi":""},{"title":"Unraveling microglial spatial organization in the developing human brain with DeepCellMap, a deep learning approach coupled with spatial statistics","authors":["Theo Perochon","Zeljka Krsnik","...","David Holcman"],"journal":"Nature Communications","date":"2025-02-13","pmid":"39948387","doi":""},{"title":"Transcriptomic profiles of monocyte-derived macrophages exposed to SARS-CoV-2 VOCs reveal immune-evasion escape driven by delta.","authors":["Alessia Gallo","Josè Camilla Sammartino","...","Fausto Baldanti"],"journal":"Journal of Translational Medicine","date":"2025-02-05","pmid":"39905461","doi":"10.1186/s12967-025-06158-2"},{"title":"An XBB.1.5-based inactivated SARS-CoV-2 vaccine partially protects against XBB.1.5 and JN.1 strains in hamsters","authors":["Ryuta Uraki","Mutsumi Ito","...","Yoshihiro Kawaoka"],"journal":"npj Viruses","date":"2025-02-03","pmid":"","doi":"10.1038/s44298-025-00096-y"},{"title":"Harnessing 2D and 3D human endometrial cell culture models to investigate SARS-CoV-2 infection in early pregnancy","authors":["Anna Liu","Natalia Ruetalo","...","Madhuri S. 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