| Catalog No. | Size | Price (USD) |
| 40588-R0004-B-20 | 20 µg | $296.22 |
| 40588-R0004-B-100 | 100 µg | $888.67 |
General Information
| Product name | SARS-CoV-2 Nucleocapsid Antibody (Biotin), Rabbit MAb |
| Validated applications | ELISA (FAQ Protocol) |
| Application notes | (Antibody's applications have not been validated with corresponding viruses. Optimal concentrations/dilutions should be determined by the end user.) |
| Specificity | SARS-CoV-2 Nucleocapsid |
| Immunogen | Recombinant SARS-CoV-2 (2019-nCoV) Nucleocapsid Protein (Catalog#40588-V08B) |
| Preparation | This product is a recombinant monoclonal antibody expressed from HEK293 cells and then biotinylated. |
| Source | Monoclonal Rabbit IgG Clone #0004 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Biotin |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Background Information
| Description | Coronaviruses are enveloped viruses with a positive-sense RNA genome and with a nucleocapsid of helical symmetry. Coronavirus nucleoproteins localize to the cytoplasm and the nucleolus, a subnuclear structure, in both virus-infected primary cells and in cells transfected with plasmids that express N protein. The coronavirus N protein is required for coronavirus RNA synthesis and has RNA chaperone activity that may be involved in template switch. Nucleocapsid protein is the most abundant protein of coronavirus. During virion assembly, N protein binds to viral RNA and leads to the formation of the helical nucleocapsid. Nucleocapsid protein is a highly immunogenic phosphoprotein also implicated in viral genome replication and in modulating cell signaling pathways. Because of the conservation of the N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool. |
| References |
|
title: Impact of age and sex on neuroinflammation following SARS-CoV-2 infection in a murine model
authors: Venkatramana D. Krishna; Allison Chang; ...; Maxim C. -J. Cheeran
journal: Frontiers in Microbiology
date: 2024-07-15
doi: 10.3389/fmicb.2024.1404312
pmcid: 11284165
cited_by_count: 0
techniques: Blocking Assay; Control; Expressing; Focus Forming Assay; Immunofluorescence; Incubation; Infection; Quantitative RT-PCR; Staining; Virus
bioz_score: 92
title: Cynomolgus Macaque Model for COVID-19 Delta Variant
authors: Seung Ho Baek; Hanseul Oh; ...; Jung Joo Hong
journal: Immune Network
date: 2022-12-01
pmid: 36627939
pmcid: 9807958
cited_by_count: 6
techniques: Blocking Assay; Histopathology; Immunohistochemistry; Incubation
bioz_score: 90
title: Mass Spectrometric Analysis of Urine from COVID-19 Patients for Detection of SARS-CoV-2 Viral Antigen and to Study Host Response
authors: Sandip Chavan; Kiran K. Mangalaparthi; ...; Akhilesh Pandey
journal: Journal of Proteome Research
date: 2021-06-02
pmid: 34077217
doi: 10.1021/acs.jproteome.1c00391
pmcid: 8189038
cited_by_count: 35
techniques: Incubation; Magnetic Beads
bioz_score: 90
