SARS-CoV-2 Omicron (B.1.1.529) Nucleocapsid Antibody, Mouse MAb
Validated applications
LFA(Det)
Application notes
IHC, FCM, IF, IP et al. applications haven't been validated. (Antibody's applications haven't been validated with corresponding virus positive samples. Optimal concentrations/dilutions should be determined by the end user.)
Specificity
SARS-CoV-2 Omicron (B.1.1.529) Nucleocapsid
Immunogen
Recombinant SARS-CoV-2 Omicron (B.1.1.529) Nucleocapsid Protein (Catalog# 40588-V07E34)
Preparation
This product is a recombinant monoclonal antibody expressed from HEK293 cells.
Source
Monoclonal Mouse IgG1 Clone #0172
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Background Information
Description
Coronaviruses are enveloped viruses with a positive-sense RNA genome and with a nucleocapsid of helical symmetry. Coronavirus nucleoproteins localize to the cytoplasm and the nucleolus, a subnuclear structure, in both virus-infected primary cells and in cells transfected with plasmids that express N protein. The coronavirus N protein is required for coronavirus RNA synthesis and has RNA chaperone activity that may be involved in template switch. Nucleocapsid protein is the most abundant protein of coronavirus. During virion assembly, N protein binds to viral RNA and leads to the formation of the helical nucleocapsid. Nucleocapsid protein is a highly immunogenic phosphoprotein also implicated in viral genome replication and in modulating cell signaling pathways. Because of the conservation of the N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool.
References
1.Van Boheemen S, et al. (2012), MBio. 3(6):e00473-12.
Bisht H. et al., 2004, Proc Natl Acad Sci. 101 (17): 6641-6.
