| Catalog No. | Size | Price (USD) |
| 50173-T16-50 | 50 µL | $147.96 |
| 50173-T16-100 | 100 µL | $251.64 |
General Information
| Product name | Anti-ACVR2B Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Mouse |
| Specificity | Mouse ACVR2B |
| Immunogen | Recombinant Mouse ACVR2B Protein (Catalog#50173-M08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Mouse ACVR2B (rM ACVR2B; Catalog#50173-M08H; NP_031423.1; Met1-Thr134). ACVR2B specific IgG was purified by Mouse ACVR2B affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-4930516B21Rik Antibody; Anti-ActRIIB Antibody; Anti-Acvr2b Antibody; Anti-AI047905 Antibody
Background Information
| Full Name | activin A receptor, type IIB |
| Description | ACVR2A and ACVR2B are two activin type II receptors. ACVR2B is integral to the activin and myostatin signaling pathway. Ligands such as activin and myostatin bind to ACVR2A and ACVR2B. Myostatin, a negative regulator of skeletal muscle growth, is regarded as a potential therapeutic target and binds to ACVR2B effectively, and to a lesser extent, to ACVR2A. The structure of human ACVR2B kinase domain in complex with adenine establishes the conserved bilobal architecture consistent with all other catalytic kinase domains. Haplotype structure at the ACVR2B and follistatin loci may contribute to interindividual variation in skeletal muscle mass and strength. Defects in ACVR2B are a cause of left-right axis malformations. |
| References |
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