| Catalog No. | Size | Price (USD) |
| 207636-T10-50 | 50 µL | $147.96 |
| 207636-T10-100 | 100 µL | $251.64 |
| 207636-T10-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-Cyclin T1/CCNT1 Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol), ICC/IF (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Cyclin T1/CCNT1 |
| Immunogen | E. coli-derived Human Cyclin T1 / CCNT1 fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human Cyclin T1 / CCNT1 fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CCNT Antibody; Anti-CYCT1 Antibody; Anti-HIVE1 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human CCNT1 in human adrenal gland with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human Cyclin T1/CCNT1 Immunohistochemistry(IHC) 26645 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining of human CCNT1 in human adrenal gland with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections. |
| Image 2 Alt Text | Human Cyclin T1/CCNT1 Immunohistochemistry(IHC) 26646 |
| Image 2 URL | Source image |
| Image 3 Description | Immunochemical staining of human CCNT1 in human adrenal gland with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections. |
| Image 3 Alt Text | Human Cyclin T1/CCNT1 Immunofluorescence(IF) 26647 |
| Image 3 URL | Source image |
Background Information
| Description | Cyclin T1 (CCNT1), a gene containing nine exons, forms the positive transcription elongation factor b (P-TEFb) complex and regulates a wide variety of biological processes including transcription. Scientists discovered a novel splice variant of CCNT1 that lacks exon 7 (dE7). dE7 regulates the expression and function of CCNT1. CCNT1 exon 7 was more frequently skipped in infected T-cells, leading to loss of the key Cyclin_N motif and affecting HIV-1 transcriptional elongation. Cells derived from mice and other rodents exhibit profound blocks to HIV-1 virion production, reflecting species-specific incompatibilities between viral Tat and Rev proteins and essential host factors cyclin T1 (CCNT1) and exportin-1 (XPO1, also known as CRM1), respectively. |
| References |
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