Anti-ADAMTSL4 Antibody, Rabbit Polyclonal sinobiological 206626-T02

$143.00
In stock
SKU
206626-T02
Catalog No.SizePrice (USD)
206626-T02-5050 µL$147.96
206626-T02-100100 µL$251.64
206626-T02-200200 µL$355.32

General Information

Product nameAnti-ADAMTSL4 Antibody, Rabbit Polyclonal
Validated applicationsICC/IF (FAQ Protocol)
Species reactivityReacts with: Human
SpecificityHuman ADAMTSL4
ImmunogenE. coli-derived Human ADAMTSL4 fragment
PreparationProduced in rabbits immunized with E. coli-derived Human ADAMTSL4 fragment, and purified by antigen affinity chromatography.
SourcePolyclonal Rabbit IgG
PurificationProtein A & Antigen Affinity
FormulationPBS, pH7.0 with 0.03% Proclin300
ConjugateUnconjugated
FormLiquid
ShippingThis antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
StorageThis antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles.

Synonyms: Anti-ADAMTSL-4 Antibody; Anti-DKFZP434K1772 Antibody; Anti-ECTOL2 Antibody; Anti-PP1396 Antibody; Anti-TSRC1 Antibody; Anti-UNQ2803/PRO34012 Antibody

Image / Experimental Information

Image 1 DescriptionImmunofluorescence staining of ADAMTSL4 in HeLa cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS,blocked with 10% serum, and incubated with rabbit anti-Human ADAMTSL4 polyclonal antibody (dilution ratio 1:200) at 4℃ overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green). Positive staining was localized to Nucleus.
Image 1 Alt TextHuman ADAMTSL4 Immunofluorescence(IF) 26545
Image 1 URLSource image

Background Information

DescriptionThe ADAMTS (a disintegrin-like and metalloproteinase domain with thrombospondin-type 1 motifs) protein superfamily includes 19 secreted metalloproteases and 7 secreted ADAMTS-like (ADAMTSL) glycoproteins. ADAMTSL4, a secreted glycoprotein, was earlier found to play a critical role in a prognostic signature for primary glioblastoma multiforme (pGBM). ADAMTSL4 mutations seem to be the most common cause of isolated ectoplia lentis (EL) and thus are important concerning the differential diagnosis of connective tissue syndromes with EL as a main feature.
References
  1. Zhao Z, et al. (2019) Adamtsl4, a secreted glycoprotein, is a novel immune-related biomarker for primary glioblastoma multiforme. Dis Markers 2019 1802620.
  2. Neuhann TM, et al. (2015) Adamtsl4-associated isolated ectopia lentis: Further patients, novel mutations and a detailed phenotype description. Am J Med Genet A 167a (10): 2376-2381.
  3. Hubmacher D, et al. (2015) Adamts proteins as modulators of microfibril formation and function. Matrix Biol 47 34-43.

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