| Catalog No. | Size | Price (USD) |
| 204680-T38-50 | 50 µL | $147.96 |
| 204680-T38-100 | 100 µL | $251.64 |
| 204680-T38-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-CYP24A1 Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol), ICC/IF (FAQ Protocol), IP (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human CYP24A1 |
| Immunogen | E. coli-derived Human CYP24A1 fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human CYP24A1 fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CP24 Antibody; Anti-CYP24 Antibody; Anti-HCAI Antibody; Anti-HCINF1 Antibody; Anti-lncBCAS1-4_1 Antibody; Anti-P450-CC24 Antibody
Image / Experimental Information
| Image 1 Description | Anti-CYP24A1 rabbit polyclonal antibody at 1:500 dilution Lane A: A431 Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:59 kDa Observed band size:59 kDa |
| Image 1 Alt Text | Human CYP24A1 Western blot (WB) 28541 |
| Image 1 URL | Source image |
| Image 2 Description | Anti-CYP24A1 rabbit polyclonal antibody at 1:500 dilution Lane A: A431 Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:59 kDa Observed band size:59 kDa |
| Image 2 Alt Text | Human CYP24A1 Immunofluorescence(IF) 28542 |
| Image 2 URL | Source image |
| Image 3 Description | Anti-CYP24A1 rabbit polyclonal antibody at 1:500 dilution Lane A: A431 Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:59 kDa Observed band size:59 kDa |
| Image 3 Alt Text | Human CYP24A1 Immunoprecipitation(IP) 28543 |
| Image 3 URL | Source image |
Background Information
| Description | CYP24A1, encoding the vitamin D-24-hydroxylase, is of major clinical and physiologic importance, serving to regulate the catabolism of 1,25-(OH)2D, the physiologically active vitamin D metabolite. In addition to facilitating catabolism of 1,25-(OH)2D, CYP24A1 also enhances the turnover and elimination of 25-OHD, the abundant precursor metabolite and storage form of the vitamin. CYP24A1, the main enzyme responsible for the degradation of active vitamin D, plays an important role in many cancer related cellular processes. Loss-of-function mutations in the CYP24A1 gene, which encodes the vitamin D-24 hydroxylase, have been recognized as a cause of elevated 1,25-dihydroxy vitamin D concentrations, hypercalcemia, hypercalciuria, nephrocalcinosis, and nephrolithiasis in infants and adults. CYP24A1, is the primary inactivating enzyme for vitamin D, potentially neutralizing the antitumor effects of calcitriol, the active form of vitamin D. |
| References |
|
-HD12NO1258-WB.png){kind=link}
-HD12NO1258-200-A549-IF.png){kind=link}
