| Catalog No. | Size | Price (USD) |
| 102050-T08-50 | 50 µL | $147.96 |
| 102050-T08-100 | 100 µL | $251.64 |
| 102050-T08-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-CYP2E1 Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human CYP2E1 |
| Immunogen | A synthetic peptide corresponding to the center region of the Human CYP2E1 |
| Preparation | Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Human CYP2E1, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CPE1 Antibody; Anti-CYP2E Antibody; Anti-P450-J Antibody; Anti-P450C2E Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human CYP2E1 in human liver with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human CYP2E1 Immunohistochemistry(IHC) 34720 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining of human CYP2E1 in human liver with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Image 2 Alt Text | Human CYP2E1 Immunohistochemistry(IHC) 34721 |
| Image 2 URL | Source image |
Background Information
| Full Name | cytochrome P450 family 2 subfamily E member 1 |
| Description | Cytochrome P450 2E1 (CYP2E1) is an important drug metabolizing enzyme for processing numerous xenobiotics in the liver, including acetaminophen and ethanol. CYP2E1 is an important mediator of RIPF development that functions by increasing cellular ER stress and ROS levels. CYP2E1 metabolizes an extensive array of pollutants, drugs, and other small molecules, often resulting in bioactivation to reactive metabolites. Increased CYP2E1 protein and activity levels can be the main cause of stress-mediated liver damage in diabetes. CYP2E1 gene encodes a drug-metabolizing enzyme that metabolizes mostly small, polar molecules, including toxic laboratory chemicals. |
title: Enzyme kinetic and in silico characterization of cytochrome P450 2E1 inhibition by hydro-ethanolic extract of Entada africana and its protective role in acetaminophen-induced hepatotoxicity.
authors: Arnaud Fondjo Kouam; Cromwel Tepap Zemnou; ...; Paul Fewou Moundipa
journal: Journal of ethnopharmacology
date: 2025-07-24
pmid: 40714060
doi: 10.1016/j.jep.2025.120315
cited_by_count: 3
bioz_score: 93
title: Integrated network pharmacology and serum metabolomics approach deciphers the anti-colon cancer mechanisms of Huangqi Guizhi Wuwu Decoction
authors: Boyu Pan; Yafei Xia; ...; Shu Yan
journal: Frontiers in Pharmacology
date: 2022-10-13
doi: 10.3389/fphar.2022.1043252
pmcid: 9607907
cited_by_count: 6
techniques: Binding Assay; CCK-8 Assay; Construct; Expressing; Quantitative RT-PCR
bioz_score: 93
title: Inhibition of CYP2E1 and activation of Nrf2 signaling pathways by a fraction from Entada africana alleviate carbon tetrachloride-induced hepatotoxicity
authors: Arnaud Fondjo Kouam; Brice Ayissi Owona; ...; Paul Fewou Moundipa
journal: Heliyon
date: 2020-08-19
pmid: 32904230
doi: 10.1016/j.heliyon.2020.e04602
pmcid: 7452572
cited_by_count: 9
techniques: Expressing; Marker; Molecular Weight; Protease Inhibitor; Protein Extraction; SYBR Green Assay; Western Blot
bioz_score: 93
title: Induction of Mkp-1 and Nuclear Translocation of Nrf2 by Limonoids from Khaya grandifoliola C.DC Protect L-02 Hepatocytes against Acetaminophen-Induced Hepatotoxicity
authors: Arnaud F. Kouam; Fei Yuan; ...; George F. Gao
journal: Frontiers in Pharmacology
date: 2017-09-19
pmid: 28974930
doi: 10.3389/fphar.2017.00653
pmcid: 5610691
cited_by_count: 14
techniques: Expressing; Isolation; Protease Inhibitor; Protein Extraction; SYBR Green Assay; Western Blot
bioz_score: 93
-HD16AU0512-100-human-liver-IHC-P.png){kind=link}
-HD16AU0512-100-human-hepatoma-IHC-P.png){kind=link}