| Catalog No. | Size | Price (USD) |
| 108772-T08-50 | 50 µL | $147.96 |
| 108772-T08-100 | 100 µL | $251.64 |
| 108772-T08-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-Cytokeratin 8 Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Cytokeratin 8 |
| Immunogen | A synthetic peptide corresponding to the C-terminus of the Human Cytokeratin 8 / KRT8 |
| Preparation | Produced in rabbits immunized with a synthetic peptide corresponding to the C-terminus of the Human Cytokeratin 8 / KRT8, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CARD2 Antibody; Anti-CK-8 Antibody; Anti-CK8 Antibody; Anti-CYK8 Antibody; Anti-K2C8 Antibody; Anti-K8 Antibody; Anti-KO Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human KRT8 in human colon carcinoma with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human Cytokeratin 8 Immunohistochemistry(IHC) 25750 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining of human KRT8 in human colon carcinoma with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections. |
| Image 2 Alt Text | Human Cytokeratin 8 Immunohistochemistry(IHC) 25751 |
| Image 2 URL | Source image |
| Image 3 Description | Immunochemical staining of human KRT8 in human colon carcinoma with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections. |
| Image 3 Alt Text | Human Cytokeratin 8 Immunohistochemistry(IHC) 25752 |
| Image 3 URL | Source image |
Background Information
| Full Name | keratin 8, type II |
| Description | KRT8 (Keratin 8) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. KRT8 is the major component of the intermediate filament cytoskeleton and is predominantly expressed in simple epithelial tissues. Aberrant expression of KRT8 is associated with multiple tumor progression and metastasis.KRT8 overexpression in renal cancer cell lines promoted cell migration and invasion. In contrast, KRT8 knockdown suppressed ccRCC metastasis both in vitro and in vivo.KRT8 expression may therefore be a biomarker or potential therapeutic target to identify patients with worse survival. Diseases associated with KRT8 include Liver Cirrhosis and Cryptogenic Cirrhosis. |
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