| Catalog No. | Size | Price (USD) |
| 310891-T32-50 | 50 µL | $147.96 |
| 310891-T32-100 | 100 µL | $251.64 |
| 310891-T32-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-Desmoglein-2 Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Desmoglein-2 |
| Immunogen | E. coli-derived Human Desmoglein-2 / DSG2 fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human Desmoglein-2 / DSG2 fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CDHF5 Antibody; Anti-HDGC Antibody
Image / Experimental Information
| Image 1 Description | Anti-Desmoglein-2 rabbit polyclonal antibody at 1:500 dilution Lane A: HepG2 Whole Cell Lysate Lane B: HeLa Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:122 kDa |
| Image 1 Alt Text | Human Desmoglein-2 Western blot (WB) 31848 |
| Image 1 URL | Source image |
Background Information
| Full Name | desmoglein 2 |
| Description | Desmoglein-2 (Dsg2) is a specific cadherin of the cell-cell contact in cardiac desmosomes. Mutations in the DSG2-gene are regarded to cause arrhythmogenic (right ventricular) cardiomyopathy (ARVC) which is a rare but severe heart muscle disease. The depletion of DSG2 markedly decreased hPSC proliferation and pluripotency marker expression. In addition, DSG2-negative population in hPSCs exhibited a notable suppression in embryonic body and teratoma formation. The actions of DSG2 in regulating the self-renewal and pluripotency of hPSCs were predominantly exerted through the regulation of beta-catenin/Slug-mediated epithelial-to-mesenchymal transition. Which demonstrate that DSG2 is a valuable PSC surface marker that is essential for the maintenance of PSC self-renewal. |
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