Anti-DKK-3 Antibody, Rabbit Polyclonal sinobiological 10203-T50
$243.00
In stock
SKU
10203-T50
| Catalog No. | Size | Price (USD) |
| 10203-T50-100 | 100 µL | $251.64 |
General Information
| Product name | Anti-DKK-3 Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol), ELISA (FAQ Protocol), ICC/IF (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human DKK-3 |
| Immunogen | Recombinant Human DKK-3 Protein (Catalog#10203-H08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human DKK-3 (rh DKK-3; Catalog#10203-H08H; AAF02676.1; Met1-Ile350). DKK-3 specific IgG was purified by Human DKK-3 affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CRRL Antibody; Anti-REIC Antibody; Anti-RIG Antibody; Anti-UNQ258/PRO295 Antibody
Image / Experimental Information
| Image 1 Description | Immunofluorescence staining of DKK3-his in A431 cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS,blocked with 10% serum, and incubated with rabbit anti-Human DKK3-his polyclonal antibody (dilution ratio 1:100) at 4℃ overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue).Positive staining was localized to Cytoplasm. |
| Image 1 Alt Text | Human DKK-3 Immunofluorescence(IF) 39097 |
| Image 1 URL | Source image |
| Image 2 Description | Immunofluorescence staining of DKK3-his in A431 cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS,blocked with 10% serum, and incubated with rabbit anti-Human DKK3-his polyclonal antibody (dilution ratio 1:100) at 4℃ overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue).Positive staining was localized to Cytoplasm. |
| Image 2 Alt Text | AcMNPV AcMNPV GP64 Western blot (WB) 39109 |
| Image 2 URL | Source image |
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-HD17OC1816-WB.png){kind=link}
Background Information
| Full Name | dickkopf WNT signaling pathway inhibitor 3 |
| Description | DKK3 (dickkopf related protein 3) is a member of the dickkopf-related family consisting of DKK1, DKK2, DKK3 and DKK4. It is a secreted protein, and also known as REIC (Reduced Expansion in Immortalized Cells). The DKK3 protein is proposed to function as a secreted tumor suppressor since it is downregulated in a number of cancer cells and prostate cancer tissue and may be a promising candidate molecule for therapeutic interference. DKK3 protein is also a negative regulator of beta-catenin and its downregulation contribute to an activation of the beta-catenin signaling pathway. |
| Related Pathways |
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| References |
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