| Catalog No. | Size | Price (USD) |
| 202489-T08-50 | 50 µL | $147.96 |
| 202489-T08-100 | 100 µL | $251.64 |
| 202489-T08-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-DNAJB14 Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human DNAJB14 |
| Immunogen | E. coli-derived Human DNAJB14 fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human DNAJB14 fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-EGNR9427 Antibody; Anti-FLJ14281 Antibody; Anti-PRO34683 Antibody; Anti-UNQ9427/PRO34683 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human DNAJB14 in human pancreas with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human DNAJB14 Immunohistochemistry(IHC) 20760 |
| Image 1 URL | Source image |
Background Information
| Description | A mammalian ER-localized transmembrane J-protein, DNAJB12, cooperates with Hsc70, a cytosolic Hsp70 family member, to promote the ERAD of misfolded membrane proteins. Mammalian genomes have another J-protein called DNAJB14 that shows a high sequence similarity to DNAJB12. DNAJB14 (DnaJ Heat Shock Protein Family (Hsp40) Member B14) is located on human chromosome 4q2. DNAJB14 is associated with some diseases, such as Erythema Infectiosum. An important paralog of this gene is DNAJB12. Like DNAJB12, DNAJB14 is an ER-localized, single membrane-spanning J-protein with its J-domain facing the cytosol. DNAJB14 can also specifically bind Hsc70 via its J-domain to recruit this chaperone to ER membrane. DNAJB14 can enhance the degradation of a misfolded membrane protein using the ubiquitin-proteasome system. |
| References |
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