| Catalog No. | Size | Price (USD) |
| 202535-T10-50 | 50 µL | $147.96 |
| 202535-T10-100 | 100 µL | $251.64 |
| 202535-T10-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-DRD1 Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol), ICC/IF (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human DRD1 |
| Immunogen | E. coli-derived Human DRD1 fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human DRD1 fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-D1R Antibody; Anti-DADR Antibody; Anti-DRD1A Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human DRD1 in human skin with rabbit polyclonal antibody at 1:125 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human DRD1 Immunohistochemistry(IHC) 21021 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining of human DRD1 in human skin with rabbit polyclonal antibody at 1:125 dilution, formalin-fixed paraffin embedded sections. |
| Image 2 Alt Text | Human DRD1 Immunofluorescence(IF) 21022 |
| Image 2 URL | Source image |
Background Information
| Full Name | Dopamine Receptor D1 |
| Description | The dopamine 1 receptor (DRD1) is thought to mediate some of the cognitive deficits in schizophrenia (SCZ), including impairment of working memory that relies on normal dorsolateral prefrontal cortex (DLPFC) function. DRD1 is a typical G protein-coupled receptor (GPCR) mainly expressed in the neurogenic area, with high constitutive activity. The receptor appears in the embryonic period before the formation of mature synaptic contacts, which indicates that the dopamine receptor and its constitutive activity play crucial roles in embryonic brain development. Cells expressing the DRD1 have significant functional roles in diverse physiological processes including locomotion and drug addiction. Neurotransmitter dopamine (DA) inhibits NLRP3 inflammasome activation via dopamine D1 receptor (DRD1). DRD1 signaling negatively regulates NLRP3 inflammasome via a second messenger cyclic adenosine monophosphate (cAMP). |
| References |
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