| Catalog No. | Size | Price (USD) |
| 50407-T24-50 | 50 µL | $147.96 |
| 50407-T24-100 | 100 µL | $251.64 |
| 50407-T24-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-Endoglin/CD105 Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol), IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Mouse |
| Specificity | Mouse Endoglin/CD105 |
| Immunogen | Recombinant Mouse Endoglin / CD105 Protein (Catalog#50407-M08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Mouse Endoglin / CD105 (rM Endoglin / CD105; Catalog#50407-M08H; NP_031958.2; Met1-Gly580). Endoglin / CD105 specific IgG was purified by Mouse Endoglin / CD105 affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CD105 Antibody; Anti-Edg Antibody; Anti-Endo Antibody; Anti-Eng Antibody; Anti-S-endoglin Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of mouse ENG in mouse liver with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Mouse Endoglin / CD105 Immunohistochemistry(IHC) 23050 |
| Image 1 URL | Source image |
Background Information
| Full Name | endoglin |
| Description | Endoglin, also known as CD105, is a type I homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated cytoplasmic tail. Endoglin contains an RGD tripeptide which is a key recognition structure in cellular adhesion,,suggesting a critical role for endoglin in the binding of endothelial cells to integrins and/or other RGD receptors. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, mesenchymal stem cells and leukemic cells of lymphoid and myeloid lineages. As an accessory receptor for the TGF-β superfamily ligands, endoglin binds TGF-β1 and TGF-β3 with high affinity not by itself but by associating with TGF-β type II receptor (TβRII) and activates the downstream signal pathways. In addition, in human umbilical vein endothelial cells, ALK-1 is also a receptor kinase for endoglin threonine phosphorylation, and mutations in either of the two genes result in the autosomal-dominant vascular dysplasia, hereditary hemorrhagic telangiectasia (HHT). Endoglin has been regarded as a powerful biomarker of neovascularization, and is associated with several solid tumor types. |
| Research Areas |
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| References |
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title: Multicompartment Polyion Complex Micelles Based on Triblock Polypept(o)ides Mediate Efficient siRNA Delivery to Cancer-Associated Fibroblasts for Antistromal Therapy of Hepatocellular Carcinoma.
authors: Paul Schneider; Heyang Zhang; ...; Matthias Barz
journal: Advanced Materials (Deerfield Beach, Fla.)
date: 2024-06-21
pmid: 38958110
doi: 10.1002/adma.202404784
cited_by_count: 12
techniques: Formalin-fixed Paraffin-Embedded; Immunohistochemistry; Incubation; Microscopy; Polymer; Software; Staining
bioz_score: 92
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