| Catalog No. | Size | Price (USD) |
| 204575-T32-50 | 50 µL | $147.96 |
| 204575-T32-100 | 100 µL | $251.64 |
| 204575-T32-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-ESRP2 Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human ESRP2 |
| Immunogen | E. coli-derived Human ESRP2 fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human ESRP2 fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-FLJ21918 Antibody; Anti-PP7059 Antibody; Anti-RBM35B Antibody
Image / Experimental Information
| Image 1 Description | Anti-ESRP2 rabbit polyclonal antibody at 1:500 dilution Lane A: Hela Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:78 kDa |
| Image 1 Alt Text | Human ESRP2 Western blot (WB) 28521 |
| Image 1 URL | Source image |
Background Information
| Description | Epithelial splicing regulatory protein 2 (ESRP2) is a conserved regulatory factor that controls the neonatal-to-adult switch of ∼20% of splice isoforms in mouse and human hepatocytes. The normal shift in splicing coincides tightly with dramatic postnatal induction of ESRP2 in hepatocytes. Forced expression of ESRP2 in immature mouse and human hepatocytes is sufficient to drive a reciprocal shift in splicing and causes various physiological abnormalities. ESRP2 deletion in mice causes excessive hepatocyte proliferation upon injury, whereas forced expression of ESRP2 inhibits proliferation by suppressing the expression of neonatal Hippo pathway isoforms. ESRP2 and its closely related isoform ESRP1 are crucial to maintain an epithelial-specific RNA splicing program. Loss of these splicing factors leads to epithelial-to-mesenchymal transition (EMT) which is an important process involved in development, tumor progression, malignant transformation, and metastasis formation. In carcinogenesis, ESRPs appear to have a context-dependent dual function. Both isoforms have been found up- or downregulated in human cancers, and both high and low expression levels were associated with poor prognosis. |
| References |
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