| Catalog No. | Size | Price (USD) |
| 204389-T02-50 | 50 µL | $147.96 |
| 204389-T02-100 | 100 µL | $251.64 |
| 204389-T02-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-FAM111B Antibody, Rabbit Polyclonal |
| Validated applications | ICC/IF (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human FAM111B |
| Immunogen | E. coli-derived Human FAM111B fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human FAM111B fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CANP Antibody; Anti-POIKTMP Antibody
Image / Experimental Information
| Image 1 Description | Immunofluorescence staining of FAM111B in U2OS cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS,blocked with 10% serum, and incubated with rabbit anti-Human FAM111B polyclonal antibody (dilution ratio 1:200) at 4℃ overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green). Positive staining was localized to Nucleus. |
| Image 1 Alt Text | Human FAM111B Immunofluorescence(IF) 24360 |
| Image 1 URL | Source image |
Background Information
| Description | FAM111B, also known as CANP or POIKTMP, is located at human chromosome 11q12.1 and encodes a protein with a trypsin-like cysteine/serine peptidase domain in the C-terminus. FAM111B is a direct target of p53. The FAM111B protein is broadly expressed in lymph node, appendix and other tissues. Structurally, the encoded protein is reported to be 84674 Da in mass. Mutations in this gene are associated with an autosomal dominant form of hereditary fibrosing poikiloderma (HFP). Affected individuals display mottled pigmentation, telangiectasia, epidermal atrophy, tendon contractures, and progressive pulmonary fibrosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
| References |
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