| Catalog No. | Size | Price (USD) |
| 204570-T40-50 | 50 µL | $147.96 |
| 204570-T40-100 | 100 µL | $251.64 |
| 204570-T40-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-FAM123A Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol), IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human FAM123A |
| Immunogen | E. coli-derived Human FAM123A fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human FAM123A fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-FAM123A Antibody; Anti-FLJ25477 Antibody
Image / Experimental Information
| Image 1 Description | Anti-FAM123A rabbit polyclonal antibody at 1:500 dilution Lane A: RT4 Whole Cell Lysate Lane B: U-251 MG Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:70 kDa Observed band size:72 kDa |
| Image 1 Alt Text | Human FAM123A Western blot (WB) 29588 |
| Image 1 URL | Source image |
| Image 2 Description | Anti-FAM123A rabbit polyclonal antibody at 1:500 dilution Lane A: RT4 Whole Cell Lysate Lane B: U-251 MG Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:70 kDa Observed band size:72 kDa |
| Image 2 Alt Text | Human FAM123A Immunohistochemistry(IHC) 29589 |
| Image 2 URL | Source image |
Background Information
| Description | Amer2 (APC membrane recruitment 2; FAM123A) is a direct interaction partner of adenomatous polyposis coli (APC), related to the tumor suppressor Amer1/WTX. FAM123A interacts with APC via two domains that bind the Armadillo repeats of APC. These domains are conserved in the related proteins Amer1/WTX (Wilms tumor gene on the X-chromosome; FAM123B), which acts as a negative regulator of Wnt signaling, and Amer3 (FAM123C). Amer1 is mutated in Wilms tumors and in the inherited disease osteopathia striata congenita with cranial sclerosis. Amer2 negatively regulates Wnt signaling probably by interfering with β-catenin. |
| References |
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