Recombinant Human Fas Ligand/FASLG Protein (Catalog#10244-H07Y)
Preparation
Produced in rabbits immunized with purified, recombinant Human Fas Ligand/FASLG (rh Fas Ligand/FASLG; Catalog#10244-H07Y; NP_000630.1; Pro134-Leu281). Fas Ligand/FASLG specific IgG was purified by Human Fas Ligand/FASLG affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
PBS, pH7.0 with 0.03% Proclin300
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles.
Fas Ligand, also known as FASLG and CD95L, is the ligand for FAS. It is a transmembrane protein which binds to TNFRSF6/FAS. Interaction of FAS with fas Ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Fas Ligand may be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.
Related Pathways
Death Receptor Signaling
p53 Pathway
References
Pitti R M. et al., 1998, Nature. 396 (6712): 699-703.
Hane M. et al., 1995, FEBS Lett. 373 (3): 265-8.
Schneider P. et al., 1997, J Biol Chem. 272 (30): 18827-33.