| Catalog No. | Size | Price (USD) |
| 202655-T36-50 | 50 µL | $147.96 |
| 202655-T36-100 | 100 µL | $251.64 |
| 202655-T36-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-AKR1B1 Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol), IP (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human AKR1B1 |
| Immunogen | E. coli-derived Human AKR1B1 fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human AKR1B1 fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-ADR Antibody; Anti-ALDR1 Antibody; Anti-ALR2 Antibody; Anti-AR Antibody
Image / Experimental Information
| Image 1 Description | Anti-AKR1B1 rabbit polyclonal antibody at 1:5000 dilution Lane A: HeLa Whole Cell Lysate Lane B: Jurkat Whole Cell Lysate Lane C: 293T Whole Cell Lysate Lane D: A431 Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:36 kDa Observed band size:36 kDa |
| Image 1 Alt Text | Human AKR1B1 Western blot (WB) 24073 |
| Image 1 URL | Source image |
| Image 2 Description | Anti-AKR1B1 rabbit polyclonal antibody at 1:5000 dilution Lane A: HeLa Whole Cell Lysate Lane B: Jurkat Whole Cell Lysate Lane C: 293T Whole Cell Lysate Lane D: A431 Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:36 kDa Observed band size:36 kDa |
| Image 2 Alt Text | Human AKR1B1 Immunoprecipitation(IP) 24074 |
| Image 2 URL | Source image |
Background Information
| Full Name | aldo-keto reductase family 1, member B1 (aldose reductase) |
| Description | Aldose reductase (AKR1B1) belongs to the aldo/keto reductase superfamily. AKR1B1 is a NADPH-dependent aldo-keto reductase best known as the rate-limiting enzyme of the polyol pathway. Expression of AKR1B1 was the highest in lens and retina. It is the first enzyme in the polyol pathway through which glucose is converted to sorbitol which is important for the function of various organs in the body, and has been implicated in the etiology of diabetic complications. AKR1B1 is quite abundant in the collecting tubule cells and thought to provide protection against hypertonic environment. Some human tissues contain AKR1B1 as well as AKR1B10, a closely related member of the aldo-keto reductase superfamily. |
| References |
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