Anti-FGFR2 Antibody, Rabbit Polyclonal sinobiological 10824-T48
$243.00
In stock
SKU
10824-T48
| Catalog No. | Size | Price (USD) |
| 10824-T48-100 | 100 µL | $251.64 |
General Information
| Product name | Anti-FGFR2 Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol), ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human FGFR2 |
| Immunogen | Recombinant Human FGFR2 Protein (Catalog#10824-H08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human FGFR2 (rh FGFR2; Catalog#10824-H08H; NP_000132.3; Met1-Glu377). FGFR2 specific IgG was purified by Human FGFR2 affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-BBDS Antibody; Anti-BEK Antibody; Anti-BFR-1 Antibody; Anti-CD332 Antibody; Anti-CEK3 Antibody; Anti-CFD1 Antibody; Anti-ECT1 Antibody; Anti-JWS Antibody; Anti-K-SAM Antibody; Anti-KGFR Antibody; Anti-KSAM Antibody; Anti-TK14 Antibody; Anti-TK25 Antibody
Image / Experimental Information
| Image 1 Description | Anti-FGFR2 rabbit polyclonal antibody at 1:500 dilution Lane A: Jurkat Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:92 kDa Observed band size:150 kDa |
| Image 1 Alt Text | Human FGFR2 Western blot (WB) 40388 |
| Image 1 URL | Source image |
Background Information
| Full Name | fibroblast growth factor receptor 2 |
| Description | FGFR2, also known as CD332, belongs to the fibroblast growth factor receptor subfamily where amino acid sequence is highly conserved between members and throughout evolution. FGFR2 acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. It is required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. FGFR2 plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. It also promotes cell proliferation in keratinocytes and imature osteoblasts, but promotes apoptosis in differentiated osteoblasts. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal CD332 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1. Defects in CD3322 are the cause of Crouzon syndrome, Jackson-Weiss syndrome, Apert syndrome, Pfeiffer syndrome, Beare-Stevenson cutis gyrata syndrome, familial scaphocephaly syndrome, lacrimo-auriculo-dento-digital syndrome and Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis. |
| Research Areas |
|
| Tags |
|
| References |
|
Reviews
Write Your Own Review
Related Products
Check items to add to the cart or
-HD17JU1412-WB.png){kind=link}