| Catalog No. | Size | Price (USD) |
| 107186-T08-100 | 100 µL | $251.64 |
General Information
| Product name | Anti-FH/Fumarate Hydratase Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Mouse, Rat, Danre, Pig, Cynomolgus (Species predicted to react based on 100% sequence homology) |
| Immunogen | A synthetic peptide corresponding to the center region of the Human FH/Fumarate Hydratase |
| Preparation | Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Human FH/Fumarate Hydratase, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-FMRD Antibody; Anti-HLRCC Antibody; Anti-HsFH Antibody; Anti-LRCC Antibody; Anti-MCL Antibody; Anti-MCUL1 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human FH in human small intestine with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human FH/Fumarate Hydratase Immunohistochemistry(IHC) 38086 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining of human FH in human small intestine with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Image 2 Alt Text | Human FH/Fumarate Hydratase Immunohistochemistry(IHC) 38087 |
| Image 2 URL | Source image |
| Image 3 Description | Immunochemical staining of human FH in human small intestine with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Image 3 Alt Text | Human FH/Fumarate Hydratase Immunohistochemistry(IHC) 38088 |
| Image 3 URL | Source image |
| Image 4 Description | Immunochemical staining of human FH in human small intestine with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Image 4 Alt Text | Human FH/Fumarate Hydratase Immunohistochemistry(IHC) 38089 |
| Image 4 URL | Source image |
| Image 5 Description | Immunochemical staining of human FH in human small intestine with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Image 5 Alt Text | Human FH/Fumarate Hydratase Immunohistochemistry(IHC) 38090 |
| Image 5 URL | Source image |
Background Information
| Full Name | fumarate hydratase |
| Description | Fumarate Hydratase (FH) is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. Fumarate Hydratase is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy. Individuals with hemizygous germline fumarate hydratase (FH) mutations are predisposed to renal cancer. These tumors predominantly exhibit functional inactivation of the remaining wild-type allele, implicating FH inactivation as a tumor-promoting event. |
| References |
|
-HD17MA2808-100-human-small intestine-IHC-P.png){kind=link}
-HD17MA2808-100-human-kidney-IHC-P.png){kind=link}
-HD17MA2808-100-Mouse-kidney-IHC-P.png){kind=link}
-HD17MA2808-100-Mouse-small intestine-IHC-P.png){kind=link}
-HD17MA2808-100-Mouse-skeletal muscle-IHC-P.png){kind=link}