| Catalog No. | Size | Price (USD) |
| 202651-T32-50 | 50 µL | $147.96 |
| 202651-T32-100 | 100 µL | $251.64 |
| 202651-T32-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-FKBP12 Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human FKBP12 |
| Immunogen | E. coli-derived Human FKBP12 fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human FKBP12 fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-FKBP-12 Antibody; Anti-FKBP-1A Antibody; Anti-FKBP1 Antibody; Anti-FKBP12 Antibody; Anti-FKBP12C Antibody; Anti-PKC12 Antibody; Anti-PKCI2 Antibody; Anti-PPIASE Antibody
Image / Experimental Information
| Image 1 Description | Anti-FKBP1A rabbit polyclonal antibody at 1:500 dilution Lane A: HL-60 Whole Cell Lysate Lane B: SH-SY5Y Whole Cell Lysate Lane C: A431 Whole Cell Lysate Lane D: U937 Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:12 kDa Observed band size:13 kDa |
| Image 1 Alt Text | Human FKBP12 Western blot (WB) 22098 |
| Image 1 URL | Source image |
Background Information
| Full Name | FK506 binding protein 1A |
| Description | FK506 binding protein 12 (FKBP12), also known as FKBP1, along with cyclophilin, are two major members of the immunophilin protein family who serve as receptors for the immunosuppressant drugs cyclosporin A and FK506. As a conserved molecule in many eukaryotes, FKBP12 has been characterized as a peptidyl-prolyl isomerase that catalyzes the transition between cis- and trans-proline residues, and is involved in several biochemical processes including protein folding, receptor signaling, protein trafficking and transcription. FKBP12 has attracted immense attention and its role in mediating the immunosuppressive functions. FKBP12 serves a dual role as a peptidyl-prolyl cis-trans isomerase and as a modulator of several cell signaling pathways. In one such role, FKBP12 interacts with and regulates the functional state of the ryanodine Ca2+ channel receptor by altering protein conformation and coordinating multi-protein complex formation. Another physiological role of FKBP12 is an interactor and a regulator of the type I serine/threonine kinase receptors of TGF-beta superfamily. Current data, derived from detailed biochemical studies as well as from functional studies in various systems, suggest that FKBP12 functions as a "guardian" for the type I receptors to prevent them from leaky signaling under sub-optimal ligand concentrations, thereby providing a molecular "gradient reader" for TGF-beta family morphogens. This aspect of FKBP12 function may be critical for cellular responsiveness to morphogenetic gradients of the TGF-beta family members during early development, serving to assure the translation of different ligand concentrations into different signaling readouts. In addition, FKBP12 may be involved in neuronal or astrocytic cytoskeletal organization and the abnormal metabolism of tau protein in Alzheimer's disease (AD) damaged neurons. |
| Research Areas |
|
| References |
|
title: Automatic Spot Identification Method for High Throughput Surface Plasmon Resonance Imaging Analysis
authors: Zhiyou Wang; Xiaoqing Huang; Zhiqiang Cheng
journal: Biosensors
date: 2018-09-13
pmid: 30217054
doi: 10.3390/bios8030085
pmcid: 6163621
cited_by_count: 8
techniques: Binding Assay; Injection; Microarray; Saline
bioz_score: 90
-HD12JU1967-WB.png){kind=link}