| Catalog No. | Size | Price (USD) |
| 204350-T08-50 | 50 µL | $147.96 |
| 204350-T08-100 | 100 µL | $251.64 |
| 204350-T08-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-FLVCR1 Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human FLVCR1 |
| Immunogen | E. coli-derived Human FLVCR1 fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human FLVCR1 fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-AXPC1 Antibody; Anti-FLVCR Antibody; Anti-MFSD7B Antibody; Anti-PCA Antibody; Anti-PCARP Antibody; Anti-SLC49A1 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human FLVCR1 in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human FLVCR1 Immunohistochemistry(IHC) 24410 |
| Image 1 URL | Source image |
Background Information
| Description | Feline leukemia virus subgroup C receptor 1 (FLVCR1), a member of the SLC49 family of four paralogous genes, is a transmembrane protein. FLVCR1 is a cell surface heme exporter, essential for erythropoiesis and systemic iron homeostasis. Disruption of FLVCR1 function blocks development of erythroid progenitors, likely due to heme toxicity. FLVCR1 has a crucial role in a variety of biological processes, including cell proliferation, cell death, apoptosis, oxidative stress response, cellular differentiation and metabolism. FLVCR1 gene mutation is in association with a clinical syndrome of posterior column ataxia with retinitis pigmentosa (PCARP). FLVCR1 may act as an oncoprotein, and have key roles in promoting proliferation and tumorigenicity of synovial sarcoma (SS), and this may shed new light on finding novel therapeutic strategies against SS. |
| References |
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