Anti-GAP-43 Antibody, Rabbit Polyclonal sinobiological 204154-T10
$243.00
In stock
SKU
204154-T10
| Catalog No. | Size | Price (USD) |
| 204154-T10-100 | 100 µL | $251.64 |
General Information
| Product name | Anti-GAP-43 Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol), ICC/IF (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human GAP-43 |
| Immunogen | E. coli-derived Human GAP-43 fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human GAP-43 fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-B-50 Antibody; Anti-GAP-43 Antibody; Anti-PP46 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human GAP43 in human brain with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human GAP-43 Immunohistochemistry(IHC) 40531 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining of human GAP43 in human brain with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Image 2 Alt Text | Human GAP-43 Immunofluorescence(IF) 40532 |
| Image 2 URL | Source image |
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Background Information
| Full Name | growth associated protein 43 |
| Description | Neuromodulin, also known as Axonal membrane protein GAP-43, Growth-associated protein 43, Neural phosphoprotein B-5, pp46 and GAP43, is a cell membrane protein which belongs to theneuromodulin family. Neuromodulin / GAP43 contains oneIQ domain. Neuromodulin / GAP43 is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Neuromodulin / GAP43 is involved in neurite outgrowth, a crucial process for the differentiation of neurons. The sudden infant death syndrome (SIDS) is the main cause of postneonatal infant death and its cause is still unknown. Neuromodulin / GAP43 is a marker of synaptic plasticity and is critical for normal development of the serotonergic innervation. Neuromodulin / GAP43 is a major cortical cytoskeleton-associated and calmodulin binding protein that is widely and abundantly expressed during development, maintained in selected brain structures in the adult, and reinduced during nerve regeneration. CAP23 and GAP43 are functionally related intrinsic determinants of anatomical plasticity. These proteins function by locally promoting subplasmalemmal actin cytoskeleton accumulation. |
| References |
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