| Catalog No. | Size | Price (USD) |
| 203905-T44-50 | 50 µL | $147.96 |
| 203905-T44-100 | 100 µL | $251.64 |
| 203905-T44-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-ALDH1A2 Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol), IHC-P (FAQ Protocol), IP (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human ALDH1A2 |
| Immunogen | E. coli-derived Human ALDH1A2 fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human ALDH1A2 fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-DIH4 Antibody; Anti-RALDH(II) Antibody; Anti-RALDH2 Antibody; Anti-RALDH2-T Antibody
Image / Experimental Information
| Image 1 Description | Anti-ALDH1A2 rabbit polyclonal antibody at 1:500 dilution Lane A: K562 Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:57 kDa Observed band size:55 kDa |
| Image 1 Alt Text | Human ALDH1A2 Western blot (WB) 28303 |
| Image 1 URL | Source image |
| Image 2 Description | Anti-ALDH1A2 rabbit polyclonal antibody at 1:500 dilution Lane A: K562 Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:57 kDa Observed band size:55 kDa |
| Image 2 Alt Text | Human ALDH1A2 Immunohistochemistry(IHC) 28304 |
| Image 2 URL | Source image |
| Image 3 Description | Anti-ALDH1A2 rabbit polyclonal antibody at 1:500 dilution Lane A: K562 Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:57 kDa Observed band size:55 kDa |
| Image 3 Alt Text | Human ALDH1A2 Immunohistochemistry(IHC) 28305 |
| Image 3 URL | Source image |
| Image 4 Description | Anti-ALDH1A2 rabbit polyclonal antibody at 1:500 dilution Lane A: K562 Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:57 kDa Observed band size:55 kDa |
| Image 4 Alt Text | Human ALDH1A2 Immunoprecipitation(IP) 28306 |
| Image 4 URL | Source image |
Background Information
| Description | Regulation of synthesis and turnover of retinoic acid (RA) is an important mechanism that controls the activity of RA signaling during vertebrate development. ALDH1A2 is a rate-limiting enzyme involved in cellular retinoic acid synthesis. ALDH1 has three main isotypes, ALDH1A1, ALDH1A2, and ALDH1A3, and is a marker of normal tissue stem cells (SC) and cancer stem cells (CSC), where it is involved in self-renewal, differentiation and self-protection. ALDH1A2 is a candidate tumor suppressor in epithelial ovarian cancer. ALDH1A2 suppresses epithelial ovarian cancer cell proliferation and migration by downregulating STAT3. Enzymes of the ALDH1A subfamily of aldehyde dehydrogenases are crucial in regulating retinoic acid (RA) signaling and have received attention as potential drug targets. |
| References |
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