Anti-GDF-15 Antibody (HRP), Mouse Monoclonal sinobiological 10936-MM12-H
$357.00
In stock
SKU
10936-MM12-H
| Catalog No. | Size | Price (USD) |
| 10936-MM12-H-100 | 100 µg | $370.28 |
General Information
| Product name | Anti-GDF-15 Antibody (HRP), Mouse Monoclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human GDF-15 |
| Immunogen | Recombinant Human GDF15/MIC-1 Protein (Catalog#10936-H07Y) |
| Preparation | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human GDF15/MIC-1 (rh GDF15/MIC-1; Catalog#10936-H07Y; NP_004855.2; Ala197-Ile308). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography and conjugated with horseradish-peroxidase (HRP). |
| Source | Monoclonal Mouse IgG1 Clone #12 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | HRP |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Protected from prolonged exposure to light. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-GDF-15 Antibody; Anti-HG Antibody; Anti-MIC-1 Antibody; Anti-MIC1 Antibody; Anti-NAG-1 Antibody; Anti-PDF Antibody; Anti-PLAB Antibody; Anti-PTGFB Antibody
Background Information
| Full Name | growth differentiation factor 15 |
| Description | Growth-differentiation factor 15 (GDF15), also known as MIC-1, is a secreted member of the transforming growth factor (TGF)-β superfamily, as a novel antihypertrophic regulatory factor in the heart. GDF-15 / GDF15 is not expressed in the normal adult heart but is induced in response to conditions that promote hypertrophy and dilated cardiomyopathy and it is expressed highly in liver. GDF-15 / GDF15 has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. GDF-15 / GDF15 is synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein. GDF-15 / GDF15 overexpression arising from an expanded erythroid compartment contributes to iron overload in thalassemia syndromes by inhibiting hepcidin expression. |
| References |
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