Anti-GFR Alpha-3/GFRA3 Antibody, Rabbit Polyclonal sinobiological 50901-T48
$243.00
In stock
SKU
50901-T48
| Catalog No. | Size | Price (USD) |
| 50901-T48-100 | 100 µL | $251.64 |
General Information
| Product name | Anti-GFR Alpha-3/GFRA3 Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol), ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Mouse |
| Specificity | Mouse GFR Alpha-3/GFRA3 |
| Immunogen | Recombinant Mouse GFR Alpha-3/GFRA3 Protein (Catalog#50901-M08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Mouse GFR Alpha-3/GFRA3 (rM GFR Alpha-3/GFRA3; Catalog#50901-M08H; NP_034410.3; Met1-Arg379). GFR Alpha-3/GFRA3 specific IgG was purified by Mouse GFR Alpha-3/GFRA3 affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-Gfra3 Antibody; Anti-GFRalpha3 Antibody
Image / Experimental Information
| Image 1 Description | Anti-GFR Alpha-3 / GFRA3 rabbit polyclonal antibody at 1:500 dilution Lane A: Mouse Kidney Tissue Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:44 kDa Observed band size:50 kDa |
| Image 1 Alt Text | Mouse GFR Alpha-3/GFRA3 Western blot (WB) 36678 |
| Image 1 URL | Source image |
Background Information
| Full Name | GDNF family receptor alpha 3 |
| Description | Glial cell line derived neurotrophic factor (GDNF) Family Receptor Alpha 3 (GFRA3) or GDNFRa3 is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. GFRA3 / GDNFRa3 is a potent survival factor for central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are its binding ligand which are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GDNF promotes the formation of a physical complex between GFRA/GDNFRa and the orphan tyrosin kinase receptor Ret, thereby inducing its tyrosine phosphorylation. The RET is a receptor tyrosine kinase representing the signal-transducing molecule of a multisubunit surface receptor complex for the GDNF, in which GFRA / GDNFRa acts as the ligand-binding component. The neurotrophic growth factor artemin binds selectively to GDNF family receptor α3 (GFRA3 / GDNFRa3), forming a molecular complex with the co-receptor RET which mediates downstream signaling. This signaling pathway has been demonstrated to play an important role in the survival and maintenance of nociceptive sensory neurons and in the development of sympathetic neurons. |
| References |
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