| Catalog No. | Size | Price (USD) |
| 205094-T08-50 | 50 µL | $147.96 |
| 205094-T08-100 | 100 µL | $251.64 |
General Information
| Product name | Anti-GIMAP6 Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human GIMAP6 |
| Immunogen | E. coli-derived Human GIMAP6 fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human GIMAP6 fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-FLJ22690 Antibody; Anti-IAN-2 Antibody; Anti-IAN-6 Antibody; Anti-IAN2 Antibody; Anti-IAN6 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human GIMAP6 in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human GIMAP6 Immunohistochemistry(IHC) 35734 |
| Image 1 URL | Source image |
Background Information
| Full Name | GTPase, IMAP family member 6 |
| Description | GIMAP6 interacts with the ATG8 family member GABARAPL2 and is recruited to autophagosomes upon starvation, suggesting a role for GIMAP6 in the autophagic process. GABARAPL2 is one of the mammalian homologs of the yeast autophagy protein Atg8. Chemical cross-linking studies performed on Jurkat T cells, which express both GIMAP6 and GABARAPL2 endogenously, indicated that the two proteins in these cells readily associate with one another in the cytosol under normal conditions. The GIMAP6-GABARAPL2 interaction was disrupted by deletion of the last 10 amino acids of GIMAP6. The N-terminal region of GIMAP6, however, which includes a putative Atg8-family interacting motif, was not required. Over-expression of GIMAP6 resulted in increased levels of endogenous GABARAPL2 in cells. GIMAP6 plays a role in modulating immune function and that it does this by controlling cell death and the activation of T cells. |
| References |
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