| Catalog No. | Size | Price (USD) |
| 200567-T02-50 | 50 µL | $147.96 |
| 200567-T02-100 | 100 µL | $251.64 |
| 200567-T02-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-GMEB1 Antibody, Rabbit Polyclonal |
| Validated applications | ICC/IF (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human GMEB1 |
| Immunogen | E. coli-derived Human GMEB1 fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human GMEB1 fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-P96PIF Antibody; Anti-PIF96 Antibody
Image / Experimental Information
| Image 1 Description | Immunofluorescence staining of GMEB1 in U251MG cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS,blocked with 10% serum, and incubated with rabbit anti-Human GMEB1 polyclonal antibody (dilution ratio 1:200) at 4℃ overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green). Positive staining was localized to . |
| Image 1 Alt Text | Human GMEB1 Immunofluorescence(IF) 25182 |
| Image 1 URL | Source image |
Background Information
| Full Name | glucocorticoid modulatory element binding protein 1 |
| Description | Glucocorticoid modulatory element binding protein (GMEB)1 and 2 are closely related proteins that modify the glucocorticoid receptor binding locus and thus modulate glucocorticoid-mediated gene induction effects, including apoptosis. GMEB1 associates with caspases and prevents apoptosis of cells in the nervous system. Manipulating GMEB may be used therapeutically to enhance the resistance or the sensitivity to steroids. GMEB1 effectively attenuated caspase activation and apoptosis caused by these stresses in human neuroblastoma SK-N-MC cells, indicating that it functions as a potent inhibitor of caspase activation and apoptosis in response to oxidative stress. That GMEB1 blocks pro-apoptosis signals induced by a variety of stresses. |
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