Anti-GOLPH2/GOLM1 Antibody, Rabbit Polyclonal sinobiological 310897-T36

$143.00
In stock
SKU
310897-T36
Catalog No.SizePrice (USD)
310897-T36-5050 µL$147.96
310897-T36-100100 µL$251.64
310897-T36-200200 µL$355.32

General Information

Product nameAnti-GOLPH2/GOLM1 Antibody, Rabbit Polyclonal
Validated applicationsWB (FAQ Protocol), IP (FAQ Protocol)
Species reactivityReacts with: Human
SpecificityHuman GOLPH2/GOLM1
ImmunogenE. coli-derived Human GOLPH2 / GOLM1 fragment
PreparationProduced in rabbits immunized with E. coli-derived Human GOLPH2 / GOLM1 fragment, and purified by antigen affinity chromatography.
SourcePolyclonal Rabbit IgG
PurificationProtein A & Antigen Affinity
FormulationPBS, pH7.0 with 0.03% Proclin300
ConjugateUnconjugated
FormLiquid
ShippingThis antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
StorageThis antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles.

Synonyms: Anti-bA379P1.3 Antibody; Anti-C9orf155 Antibody; Anti-FLJ23608 Antibody; Anti-GOLPH2 Antibody; Anti-GP73 Antibody; Anti-HEL46 Antibody; Anti-PSEC0242 Antibody; Anti-PSEC0257 Antibody; Anti-UNQ686/PRO1326 Antibody

Image / Experimental Information

Image 1 DescriptionAnti-GOLPH2/GOLM1 rabbit polyclonal antibody at 1:500 dilution Lane A: MDA-MB-231 Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:45 kDa
Image 1 Alt TextHuman GOLPH2/GOLM1 Western blot (WB) 31855
Image 1 URLSource image
Image 2 DescriptionAnti-GOLPH2/GOLM1 rabbit polyclonal antibody at 1:500 dilution Lane A: MDA-MB-231 Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:45 kDa
Image 2 Alt TextHuman GOLPH2/GOLM1 Immunoprecipitation(IP) 31856
Image 2 URLSource image

Background Information

Full Namegolgi membrane protein 1
DescriptionGolgi membrane protein 1, also known as Golgi membrane protein GP73, Golgi phosphoprotein 2, and GOLM1, is a protein that belongs to the GOLM1 / CASC4 family. GOLM1 is widely expressed. It is highly expressed in the colon, prostate, trachea, and stomach. It is expressed at a lower level in testis, muscle, lymphoid tissues, white blood cells, and spleen. It is predominantly expressed by cells of the epithelial lineage. GOLM1 is expressed at a low level in the normal liver. Expression significantly increases in virus (HBV, HCV) infected liver. Expression of GOLM1 does not increase in liver disease due to non-viral causes (alcohol-induced liver disease, autoimmune hepatitis). Increased expression in hepatocytes appears to be a general feature of advanced liver disease. In liver tissue from patients with adult giant-cell hepatitis (GCH), GOLM1 is strongly expressed in hepatocyte-derived syncytial giant cells. GOLM1 is constitutively expressed by biliary epithelial cells but not by hepatocytes.
References
  1. Kladney R.D., et al. ,(2000), GP73, a novel Golgi-localized protein upregulated by viral infection. Gene 249:53-65.
  2. Clark H.F., et al. , (2003), The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.Genome Res. 13:2265-2270.
  3. Puri S., et al. ,(2002), Cycling of early Golgi proteins via the cell surface and endosomes upon lumenal pH disruption.Traffic 3:641-653.

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