Anti-ALMS1 Antibody, Rabbit Polyclonal sinobiological 205863-T08

$143.00
In stock
SKU
205863-T08
Catalog No.SizePrice (USD)
205863-T08-5050 µL$147.96
205863-T08-100100 µL$251.64
205863-T08-200200 µL$355.32

General Information

Product nameAnti-ALMS1 Antibody, Rabbit Polyclonal
Validated applicationsIHC-P (FAQ Protocol)
Species reactivityReacts with: Human
SpecificityHuman ALMS1
ImmunogenE. coli-derived Human ALMS1 fragment
PreparationProduced in rabbits immunized with E. coli-derived Human ALMS1 fragment, and purified by antigen affinity chromatography.
SourcePolyclonal Rabbit IgG
PurificationProtein A & Antigen Affinity
FormulationPBS, pH7.0 with 0.03% Proclin300
ConjugateUnconjugated
FormLiquid
ShippingThis antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
StorageThis antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles.

Synonyms: Anti-ALSS Antibody; Anti-KIAA0328 Antibody

Image / Experimental Information

Image 1 DescriptionImmunochemical staining of human ALMS1 in human rectum with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.
Image 1 Alt TextHuman ALMS1 Immunohistochemistry(IHC) 26085
Image 1 URLSource image

Background Information

Full NameALMS1 centrosome and basal body associated protein
DescriptionALMS1 is a large (> 4000 residue) protein that lacks known catalytic domains. It has several sequence features of unknown function, including a large tandem repeat domain (TRD), three short predicted coiled-coil domains and a stretch of ~ 130 residues at the C-terminus dubbed the ALMS motif. The ALMS motif is the only region that shares obvious sequence similarity with other human proteins. The ALMS1 protein is a component of the centrosome, a microtubule (MT)-nucleating organelle comprising two centrioles (termed mother and daughter) and a dynamic assembly of proteins termed pericentriolar material (PCM).ALMS1 is involved in several processes including endosomal trafficking, actin organization, maintenance of centrosome cohesion and transcription.
References
  1. Hearn T (2019) Alms1 and alström syndrome: A recessive form of metabolic, neurosensory and cardiac deficits. J Mol Med (Berl) 97 (1): 1-17.

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