Produced in rabbits immunized with E. coli-derived Human ALMS1 fragment, and purified by antigen affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
PBS, pH7.0 with 0.03% Proclin300
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles.
ALMS1 centrosome and basal body associated protein
Description
ALMS1 is a large (> 4000 residue) protein that lacks known catalytic domains. It has several sequence features of unknown function, including a large tandem repeat domain (TRD), three short predicted coiled-coil domains and a stretch of ~ 130 residues at the C-terminus dubbed the ALMS motif. The ALMS motif is the only region that shares obvious sequence similarity with other human proteins. The ALMS1 protein is a component of the centrosome, a microtubule (MT)-nucleating organelle comprising two centrioles (termed mother and daughter) and a dynamic assembly of proteins termed pericentriolar material (PCM).ALMS1 is involved in several processes including endosomal trafficking, actin organization, maintenance of centrosome cohesion and transcription.
References
Hearn T (2019) Alms1 and alström syndrome: A recessive form of metabolic, neurosensory and cardiac deficits. J Mol Med (Berl) 97 (1): 1-17.