| Catalog No. | Size | Price (USD) |
| 11688-RP01-20 | 20 µL | $88.87 |
| 11688-RP01-100 | 100 µL | $251.64 |
| 11688-RP01-200 | 200 µL | $370.28 |
General Information
| Product name | Influenza A H2N2 Hemagglutinin / HA Antibody, Rabbit PAb |
| Validated applications | WB (FAQ Protocol), ELISA (FAQ Protocol) |
| Application notes | IHC, FCM, IF, IP et al. applications haven't been validated. (Antibody's applications haven't been validated with corresponding virus positive samples. Optimal concentrations/dilutions should be determined by the end user.) |
| Specificity | H2N2 (A/Canada/720/2005) HA / Hemagglutinin |
| Immunogen | Recombinant H2N2 (A/Canada/720/2005) HA / Hemagglutinin protein (Catalog#11688-V08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant H2N2 (A/Canada/720/2005) HA / Hemagglutinin (Catalog#11688-V08H; AAY28987.1; Met 1-Gln 516). Total IgG was purified by Protein A affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Background Information
| Full Name | Hemagglutinin |
| Description | The influenza viral Hemagglutinin (HA) protein is a homotrimer with a receptor binding pocket on the globular head of each monomer.HA has at least 18 different antigens. These subtypes are named H1 through H18.HA has two functions. Firstly, it allows the recognition of target vertebrate cells, accomplished through the binding to these cells' sialic acid-containing receptors. Secondly, once bound it facilitates the entry of the viral genome into the target cells by causing the fusion of the host endosomal membrane with the viral membrane. The influenza virus Hemagglutinin (HA) protein is translated in cells as a single protein, HA, or hemagglutinin precursor protein. For viral activation, hemagglutinin precursor protein (HA) must be cleaved by a trypsin-like serine endoprotease at a specific site, normally coded for by a single basic amino acid (usually arginine) between the HA1 and HA2 domains of the protein. After cleavage, the two disulfide-bonded protein domains produce the mature form of the protein subunits as a prerequisite for the conformational change necessary for fusion and hence viral infectivity. |
| References |
|
title: Adeno‐associated virus‐vectored influenza vaccine elicits neutralizing and Fcγ receptor‐activating antibodies
authors: Daniel E Demminger; Lisa Walz; ...; Thorsten Wolff
journal: EMBO Molecular Medicine
date: 2020-03-12
pmid: 32163240
doi: 10.15252/emmm.201910938
pmcid: 7207162
cited_by_count: 33
techniques: Construct; Cytometry; Expressing; Flow Cytometry; Generated; Immunofluorescence; Laser-Scanning Microscopy; Membrane; Microscopy; Modification; Plasmid Preparation; Staining; Transduction; Transfection; Western Blot
bioz_score: 95
title: Kallistatin Ameliorates Influenza Virus Pathogenesis by Inhibition of Kallikrein-Related Peptidase 1-Mediated Cleavage of Viral Hemagglutinin
authors: Chia-Hsing Leu; Mei-Lin Yang; ...; Ai-Li Shiau
journal: Antimicrobial Agents and Chemotherapy
date: 2015-09-01
pmid: 26149981
doi: 10.1128/AAC.00065-15
pmcid: 4538499
cited_by_count: 11
techniques: Imaging; Software; Western Blot
bioz_score: 95
