| Catalog No. | Size | Price (USD) |
| 10004-R002A-B-100 | 100 µg | $518.39 |
General Information
| Product name | Recombinant Anti-Her2/ERBB2 Antibody (Biotin), Rabbit Monoclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Her2/ERBB2 |
| Immunogen | Recombinant Human HER2/ErbB2/CD340 Protein (Catalog#10004-H08H) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Human HER2/ErbB2/CD340 (rh HER2/ErbB2/CD340; Catalog#10004-H08H; NP_004439.2; Met1-Thr652) and then biotinylated. |
| Source | Monoclonal Rabbit IgG Clone #002 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Biotin |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-c-ERB-2 Antibody; Anti-c-ERB2 Antibody; Anti-CD340 Antibody; Anti-HER-2 Antibody; Anti-HER-2/neu Antibody; Anti-HER2 Antibody; Anti-MLN 19 Antibody; Anti-MLN-19 Antibody; Anti-MLN19 Antibody; Anti-NEU Antibody; Anti-NGL Antibody; Anti-p185(erbB2) Antibody; Anti-TKR1 Antibody; Anti-VSCN2 Antibody
Background Information
| Full Name | erb-b2 receptor tyrosine kinase 2 |
| Description | Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on. |
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