Anti-Her2/ERBB2 Antibody, Rabbit Polyclonal sinobiological 10004B-T16
$243.00
In stock
SKU
10004B-T16
| Catalog No. | Size | Price (USD) |
| 10004B-T16-100 | 100 µL | $251.64 |
General Information
| Product name | Anti-Her2/ERBB2 Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Her2/ERBB2 |
| Immunogen | Recombinant cytoplasmic domain Human HER2 / ErbB2 Protein (Catalog#10004-H20B1) |
| Preparation | Produced in rabbits immunized with purified, recombinant cytoplasmic domain Human Her2/ERBB2 (rh Her2/ERBB2; Catalog#10004-H20B1; NP_004439.2; Lys676-Val1255). Her2/ERBB2 specific IgG was purified by Human Her2/ERBB2 affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-c-ERB-2 Antibody; Anti-c-ERB2 Antibody; Anti-CD340 Antibody; Anti-HER-2 Antibody; Anti-HER-2/neu Antibody; Anti-HER2 Antibody; Anti-MLN 19 Antibody; Anti-MLN-19 Antibody; Anti-MLN19 Antibody; Anti-NEU Antibody; Anti-NGL Antibody; Anti-p185(erbB2) Antibody; Anti-TKR1 Antibody; Anti-VSCN2 Antibody
Background Information
| Full Name | erb-b2 receptor tyrosine kinase 2 |
| Description | Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on. |
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