| Catalog No. | Size | Price (USD) |
| 51003-R138-H-100 | 100 µg | $518.39 |
General Information
| Product name | Recombinant Anti-HER3/ERBB3 Antibody (HRP), Rabbit Monoclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Mouse |
| Specificity | Mouse HER3/ERBB3 |
| Immunogen | Recombinant Mouse HER3 / ErbB3 protein (Catalog#51003-M08H) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse HER3 / ErbB3 (rM HER3 / ErbB3; Catalog#51003-M08H; Q61526; Met1-His641), and conjugated with horseradish-peroxidase (HRP). |
| Source | Monoclonal Rabbit IgG Clone #138 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | HRP |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Protected from prolonged exposure to light. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-Erbb-3 Antibody; Anti-Erbb3 Antibody; Anti-Erbb3r Antibody; Anti-Her3 Antibody
Background Information
| Full Name | erb-b2 receptor tyrosine kinase 3 |
| Description | ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form. |
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