Anti-HGF Activator/HGFA Antibody, Rabbit Polyclonal sinobiological 10329-T16
$243.00
In stock
SKU
10329-T16
| Catalog No. | Size | Price (USD) |
| 10329-T16-100 | 100 µL | $251.64 |
General Information
| Product name | Anti-HGF Activator/HGFA Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human HGF Activator/HGFA |
| Immunogen | Recombinant Human HGF Activator/HGFA Protein (Catalog#10329-H08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human HGF Activator/HGFA (rh HGF Activator/HGFA; Catalog#10329-H08H; NP_001519.1; Met1-Ser655). HGF Activator/HGFA specific IgG was purified by Human HGF Activator/HGFA affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-HGFA Antibody; Anti-HGFAP Antibody
Background Information
| Description | HGF activator (HGFA) is a serum-derived serine protease and belongs to the peptidase family S1.HGFA is responsible for the conversion of hepatocyte growth factor (HGF), from the inactive single-chain precursor to the active heterodimeric form, which is a potent mitogen, motogen, and morphogen for liver cells, epithelial cells, and endothelial cells. HGFA is synthesized and secreted by the liver and circulates in the plasma as an inactive single-chain zymogen in normal states. The zymogen is cleaved by thrombin or thermolysin through the endoproteolytic process and forms an active heterodimer linked by a disulfide bond. In turn, the active protease can be inhibited by HGFA inhibitors (HAIs) including HAI-1 and HAI-2. Besides, the HGFA zymogen acquires a strong affinity upon activation and thus may ensure the local action in tissue regeneration in the liver, kidney, and skin. It has been reported that activation of HGF is a critical limiting step in the HGF/SF-induced signaling pathway mediated by Met, and accordingly, aberrant expression of HGFA is implicated in tumorigenesis and progression. |
| Research Areas |
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