Anti-AMIGO2 Antibody, Rabbit Polyclonal sinobiological 201249-T08

$143.00
In stock
SKU
201249-T08
Catalog No.SizePrice (USD)
201249-T08-5050 µL$147.96
201249-T08-100100 µL$251.64
201249-T08-200200 µL$355.32

General Information

Product nameAnti-AMIGO2 Antibody, Rabbit Polyclonal
Validated applicationsIHC-P (FAQ Protocol)
Species reactivityReacts with: Human
SpecificityHuman AMIGO2
ImmunogenE. coli-derived Human AMIGO2 fragment
PreparationProduced in rabbits immunized with E. coli-derived Human AMIGO2 fragment, and purified by antigen affinity chromatography.
SourcePolyclonal Rabbit IgG
PurificationProtein A & Antigen Affinity
FormulationPBS, pH7.0 with 0.03% Proclin300
ConjugateUnconjugated
FormLiquid
ShippingThis antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
StorageThis antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles.

Synonyms: Anti-ALI1 Antibody; Anti-AMIGO-2 Antibody; Anti-DEGA Antibody

Image / Experimental Information

Image 1 DescriptionImmunochemical staining of human AMIGO2 in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.
Image 1 Alt TextHuman AMIGO2 Immunohistochemistry(IHC) 23266
Image 1 URLSource image
Image 2 DescriptionImmunochemical staining of human AMIGO2 in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.
Image 2 Alt TextHuman AMIGO2 Immunohistochemistry(IHC) 23267
Image 2 URLSource image

Background Information

Full Nameadhesion molecule with Ig-like domain 2
DescriptionAMIGO2 contains Ig-like C2-type (immunoglobulin-like) domain, 6 LRR (leucine-rich) repeats, 1 LRRCT domain and 1 LRRNT domain. It belongs to the immunoglobulin superfamily, AMIGO family. AMIGO2 may mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. It is required for depolarization-dependent survival of cultured cerebellar granule neurons. AMIGO2 may also contribute to signal transduction through its intracellular domain. It may play a role in the tumorigenesis of a subset of gastric adenocarcinomas. AMIGO2 is highly expressed in breast, ovary, cervix, and uterus.
References
  1. Rouhiainen A, et al. (2003) AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats. J Cell Biol. 160:963-73.
  2. Kikkawa Y, et al. (2003) Alivin 1, a novel neuronal activity-dependent gene, inhibits apoptosis and promotes survival of cerebellar granule neurons. J Neurosci. 23:5887-96.
  3. Bassi R, et al. (2004) DEGA/AMIGO-2, a leucine-rich repeat family member, differentially expressed in human gastric adenocarcinoma: effects on ploidy, chromosomal stability, cell adhesion/migration and tumorigenicity. Oncogene 23:5056-67.

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