| Catalog No. | Size | Price (USD) |
| 201552-T10-50 | 50 µL | $147.96 |
| 201552-T10-100 | 100 µL | $251.64 |
| 201552-T10-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-AMMECR1 Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol), ICC/IF (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human AMMECR1 |
| Immunogen | E. coli-derived Human AMMECR1 fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human AMMECR1 fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-AMMERC1 Antibody; Anti-MFHIEN Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human AMMECR1 in human rectum with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human AMMECR1 Immunohistochemistry(IHC) 22912 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining of human AMMECR1 in human rectum with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Image 2 Alt Text | Human AMMECR1 Immunofluorescence(IF) 22913 |
| Image 2 URL | Source image |
Background Information
| Description | AMMECR1 is potentially involved in cell cycle control and linked to a new syndrome with growth, bone, heart, and kidney alterations with or without elliptocytosis. AMMECR1 is composed of six exons, shows a ubiquitous 6.5-kb transcript, and codes for a protein with a molecular mass of 35.5 kDa. AMMECR1 gene is localized in the critical region of contiguous deletion syndrome on Xq22.3 implicated in Alport syndrome, mental retardation, midface hypoplasia, and elliptocytosis (AMME complex). AMMECR1 plays a critical role in cell proliferation, cell-cycle progression, and apoptosis of human lung cancer cells, and may serve as a potential therapeutic target for non-small-cell lung cancer. |
| References |
|
title: Hearing loss, cleft palate, and congenital hip dysplasia in female carriers of an intragenic deletion of AMMECR1
authors: Saskia Koene; Jeroen Knijnenburg; ...; Liselotte J. C. Rotteveel
journal: American journal of medical genetics. Part A
date: 2022-01-27
pmid: 35084080
doi: 10.1002/ajmg.a.62669
pmcid: 9305766
cited_by_count: 3
techniques: Immunohistochemistry; Incubation; Staining
bioz_score: 90
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