| Catalog No. | Size | Price (USD) |
| 13623-RP01-100 | 100 µL | $147.96 |
| 13623-RP01-200 | 200 µL | $251.64 |
| 13623-RP01-400 | 400 µL | $355.32 |
General Information
| Product name | Anti-ABP1/AOC1 Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human ABP1/AOC1 |
| Immunogen | Recombinant Human ABP1 protein (Catalog#13623-H08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Human ABP1 (rh AOC1; Catalog#13623-H08H; AAH14093.1; Met1-Val751). Total IgG was purified by Protein A affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-ABP Antibody; Anti-ABP1 Antibody; Anti-DAO Antibody; Anti-DAO1 Antibody; Anti-KAO Antibody; Anti-KDAO Antibody
Background Information
| Full Name | amine oxidase, copper containing 1 |
| Description | Amine oxidase copper-containing 1 (AOC1; formerly known as amiloride-binding protein 1) is a secreted glycoprotein that catalyzes the degradation of putrescine and histamine. Polyamines and their diamine precursor putrescine are ubiquitous to all organisms and fulfill pivotal functions in cell growth and proliferation. That the Wilms tumor protein, WT1, which is necessary for normal kidney development, activates transcription of the AOC1 gene. Expression of a firefly luciferase reporter under control of the proximal AOC1 promoter was significantly enhanced by co-transfection of a WT1 expression construct. Binding of WT1 protein to a cis-regulatory element in the AOC1 promoter was confirmed by electrophoretic mobility shift assay and chromatin immunoprecipitation. WT1-dependent control of polyamine breakdown, which is mediated by changes in AOC1 expression, has a role in kidney organogenesis. |
