| Catalog No. | Size | Price (USD) |
| 10108-RP01-20 | 20 µL | $88.87 |
| 10108-RP01-50 | 50 µL | $340.51 |
| 10108-RP01-100 | 100 µL | $192.40 |
| 10108-RP01-200 | 200 µL | $251.64 |
| 10108-RP01-400 | 400 µL | $355.32 |
General Information
| Product name | Anti-ACE2 Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol), IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human ACE2 |
| Immunogen | Recombinant Human ACE2 / Angiotensin-Converting Enzyme 2 Protein |
| Preparation | Produced in rabbits immunized with purified, recombinant Human ACE2 / Angiotensin-Converting Enzyme 2 (rh ACE2 / Angiotensin-Converting Enzyme 2; NP_068576.1; 1M-740S). Total IgG was purified by Protein A affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-ACEH Antibody; Anti-UNQ868/PRO1885 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human ACE2 in human kidney with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human ACE2 Immunohistochemistry(IHC) 29800 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining of human ACE2 in human kidney with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections. |
| Image 2 Alt Text | Human ACE2 Immunohistochemistry(IHC) 29801 |
| Image 2 URL | Source image |
Background Information
| Full Name | angiotensin I converting enzyme 2 |
| Description | Angiotensin-converting enzyme 2 (ACE2), a first homolog of ACE, regulates the renin angiotensin system (RAS) by counterbalancing ACE activity. Accumulating evidence in recent years has demonstrated a physiological and pathological role of ACE2 in the cardiovascular, renal and respiratory systems. ACE2 also has an important role in blood pressure control. This enzyme, an homolog of ACE, hydrolyzes angiotensin (Ang) I to produce Ang-(1-9), which is subsequently converted into Ang-(1-7) by a neutral endopeptidase and ACE. ACE2 releases Ang-(1-7) more efficiently than its catalysis of Ang-(1-9) by cleavage of Pro(7)-Phe(8) bound in Ang II. Thus, the major biologically active product of ACE2 is Ang-(1-7), which is considered to be a beneficial peptide of the RAS cascade in the cardiovascular system. A physiological role for ACE2 has been implicated in hypertension, cardiac function, heart function and diabetes, and as a receptor of the severe acute respiratory syndrome coronavirus. In the acute respiratory distress syndrome (ARDS), ACE, AngII, and AT1R promote the disease pathogenesis, whereas ACE2 and the AT2R protect from ARDS. Importantly, ACE2 has been identified as a key SARS-coronavirus receptor and plays a protective role in severe acute respiratory syndrome (SARS) pathogenesis. Furthermore, the recent explosion of research into the ACE2 homolog, collectrin, has revealed a new physiological function of ACE2 as an amino acid transporter, which explains the pathogenic role of gene mutations in Hartnup disorder. This review summarizes and discusses the recently unveiled roles for ACE2 in disease pathogenesis. |
| References |
|
[{"title":"A biosafe mouse model for SARS-CoV-2 infection that more realistically simulates COVID-19 symptoms","authors":["Xiaoya Huang","Yingjian Li","...","Yu Chen"],"journal":"Signal transduction and targeted therapy","date":"2026-03-16","pmid":"41839853","doi":"","pmcid":"","cited_by_count":0,"techniques":["Expressing","Gene Expression","Histopathology","Imaging","Immunofluorescence","Infection","Injection","Knock-In","Marker","Sequencing","Staining","Western Blot"],"bioz_score":"94"},{"title":"UHRF1 restricts HCoV-229E infection through epigenetic silencing of the viral receptor APN","authors":["Pengcheng Wang","Ziqiao Wang","...","Rong Zhang"],"journal":"Nature Communications","date":"2025-11-18","pmid":"41253770","doi":"10.1038/s41467-025-64977-9","pmcid":"","cited_by_count":0,"techniques":["Activation Assay","Activity Assay","Binding Assay","Biomarker Discovery","Blocking Assay","CRISPR","Chromatin Immunoprecipitation","Confocal Microscopy","Control","DNA 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particles","authors":["Li Yingjian","Huang Xiaoya","...","Chen Yu"],"journal":"bioRxiv","date":"2024-11-10","pmid":"","doi":"10.1101/2024.11.10.622838","pmcid":"","cited_by_count":0,"techniques":["Histopathology"],"bioz_score":"94"},{"title":"Blood-brain barrier injury and neuroinflammation induced by SARS-CoV-2 in a lung-brain microphysiological system.","authors":["Peng Wang","Lin Jin","...","Jianhua Qin"],"journal":"Nature Biomedical Engineering","date":"2024-09-04","pmid":"37349391","doi":"10.1038/s41551-023-01054-w","pmcid":"","cited_by_count":46,"techniques":["Chromatin Immunoprecipitation","Flow Cytometry","Immunofluorescence","Magnetic Resonance Imaging","Western Blot"],"bioz_score":"94"},{"title":"Epitranscriptomic m 5 C methylation of SARS-CoV-2 RNA regulates viral replication and the virulence of progeny viruses in the new infection","authors":["Hongyun Wang","Jiangpeng Feng","...","Yu Chen"],"journal":"Science Advances","date":"2024-08-09","pmid":"","doi":"10.1126/sciadv.adn9519","pmcid":"11305390","cited_by_count":0,"techniques":["Blocking Assay","Immunofluorescence","Infection","Lysis","Membrane","Nucleic Acid Electrophoresis","Radio Immunoprecipitation","Saline","Staining","Variant Assay","Western Blot"],"bioz_score":"94"},{"title":"A broad neutralizing nanobody against SARS-CoV-2 engineered from an approved drug","authors":["Qianyun Liu","Yuchi Lu","...","Yi Xiong"],"journal":"Cell death & disease","date":"2024-06-28","pmid":"38937437","doi":"10.1038/s41419-024-06802-7","pmcid":"11211474","cited_by_count":7,"techniques":["Binding Assay","Comparison","Confocal Microscopy","Cryo-EM Sample Prep","Immunofluorescence","Infection","Staining","Virus"],"bioz_score":"94"},{"title":"Natural evidence of coronaviral 2′-O-methyltransferase activity affecting viral pathogenesis via improved substrate RNA binding","authors":["Jikai Deng","Shimin Yang","...","Yu Chen"],"journal":"Signal transduction and 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neutralization","authors":["Zhang Lu","Cheng Hsiu-Hsin","...","Hoffmann Markus"],"journal":"bioRxiv","date":"2024-04-18","pmid":"","doi":"10.1101/2024.04.18.590061","pmcid":"","cited_by_count":1,"techniques":["Activity Assay","Binding Assay","Blocking Assay","Derivative Assay","Expressing","Flow Cytometry","Incubation","Luciferase","Neutralization","Plasmid Preparation","Recombinant","Transduction","Transfection","Two Tailed Test","Virus","Western Blot"],"bioz_score":"94"},{"title":"Calpain-2 mediates SARS-CoV-2 entry via regulating ACE2 levels","authors":["Qiru Zeng","Avan Antia","...","Peter Palese"],"journal":"mBio","date":"2024-03-01","pmid":"38349185","doi":"10.1128/mbio.02287-23","pmcid":"10936414","cited_by_count":3,"techniques":["Binding Assay","Blocking Assay","Centrifugation","Flow Cytometry","Incubation","Infection","Membrane","Quantitative RT-PCR","RNA Extraction","Staining","Virus","Western Blot"],"bioz_score":"94"},{"title":"SARS-CoV-2 spike-reactive naïve B cells and pre-existing memory B cells contribute to antibody responses in unexposed individuals after vaccination","authors":["Shishan Teng","Yabin Hu","...","Xiaowang Qu"],"journal":"Frontiers in Immunology","date":"2024-02-14","pmid":"","doi":"10.3389/fimmu.2024.1355949","pmcid":"10899457","cited_by_count":1,"techniques":["Binding Assay","Blocking Assay","Incubation","Staining"],"bioz_score":"93"},{"title":"A novel hACE2 knock-in mouse model recapitulates pulmonary and intestinal SARS-CoV-2 infection.","authors":["Xiaoyang Zhou","Weiyang Sun","...","Jintao Li"],"journal":"Frontiers in Microbiology","date":"2023-02-27","pmid":"37350787","doi":"","pmcid":"","cited_by_count":7,"techniques":["Expressing","Protein Extraction","Sequencing"],"bioz_score":"94"},{"title":"Calpain-2 mediates SARS-CoV-2 entry and represents a therapeutic target","authors":["Zeng Qiru","Antia Avan","...","Ding Siyuan"],"journal":"bioRxiv","date":"2022-11-29","pmid":"","doi":"","pmcid":"","cited_by_count":0,"techniques":["Binding Assay","Confocal Microscopy","Imaging","Incubation","Infection","Microscopy","Quantitative RT-PCR","RNA Extraction","Staining","Western Blot","Whole Genome Amplification"],"bioz_score":"94"},{"title":"LRRC15 inhibits SARS-CoV-2 cellular entry in trans.","authors":["Jaewon Song","Ryan D Chow","...","Sanghyun Lee"],"journal":"PLoS Biology","date":"2022-10-27","pmid":"36228039","doi":"","pmcid":"","cited_by_count":15,"techniques":["Binding Assay","Blocking Assay","Concentration Assay","Enzyme-linked Immunosorbent Assay","Incubation","Recombinant","Software","Staining"],"bioz_score":"94"},{"title":"Dimethoxycurcumin Acidifies Endolysosomes and Inhibits SARS-CoV-2 Entry","authors":["Nabab Khan","Zahra Afghah","...","Xuesong Chen"],"journal":"Frontiers in Virology","date":"2022-06-30","pmid":"","doi":"10.3389/fviro.2022.923018","pmcid":"","cited_by_count":3,"techniques":["Bradford Protein Assay","Centrifugation","Imaging","Incubation","Lysis","Protease Inhibitor","SDS Page","Western Blot"],"bioz_score":"94"},{"title":"Cardiopulmonary Injury in the Syrian Hamster Model of COVID-19","authors":["Yi Xue","Dong Yang","...","Xavier Clemente-Casares"],"journal":"Viruses","date":"2022-06-27","pmid":"35891384","doi":"10.3390/v14071403","pmcid":"9316644","cited_by_count":8,"techniques":["Activity Assay","Immunohistochemistry","Immunostaining","Plasmid Preparation","Staining"],"bioz_score":"94"},{"title":"Differential susceptibility to SARS‐CoV‐2 in the normal nasal mucosa and in chronic sinusitis","authors":["Zhili Zhang","Haoran Peng","...","Shaoqing Yu"],"journal":"European Journal of Immunology","date":"2022-05-14","pmid":"35524548","doi":"10.1002/eji.202249805","pmcid":"9347577","cited_by_count":3,"techniques":["Expressing","Immunofluorescence","Immunostaining","Infection","Microscopy","Quantitative RT-PCR","Staining"],"bioz_score":"93"},{"title":"Enhanced trimeric ACE2 exhibits potent prophylactic and therapeutic efficacy against the SARS-CoV-2 Delta and Omicron variants in vivo","authors":["Mengjiao Li","Zi-Wei Ye","...","Bobo Dang"],"journal":"Cell Research","date":"2022-04-13","pmid":"35418217","doi":"10.1038/s41422-022-00656-4","pmcid":"9007249","cited_by_count":6,"techniques":["Expressing","Incubation","Purification"],"bioz_score":"93"},{"title":"Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model.","authors":["Sheng Jiang","Shuting Wu","...","Bin Wang"],"journal":"Human Vaccines & Immunotherapeutics","date":"2022-04-06","pmid":"35061975","doi":"","pmcid":"","cited_by_count":2,"techniques":["Binding Assay","Blocking Assay","Concentration Assay","Electroporation","Enzyme-linked Immunosorbent Assay","Functional Assay","Incubation","Isolation","Modification","Neutralization","Virus"],"bioz_score":"94"},{"title":"A second functional furin site in the SARS-CoV-2 spike protein","authors":["Yue Zhang","Li Zhang","...","Youchun Wang"],"journal":"Emerging microbes & infections","date":"2022-01-04","pmid":"34856891","doi":"10.1080/22221751.2021.2014284","pmcid":"8741242","cited_by_count":35,"techniques":["Activation Assay","Expressing","Generated","Infection","Luciferase","Microscopy","Plasmid Preparation","Recombinant","SDS Page","Transfection","Transgenic Assay","Western Blot"],"bioz_score":"94"},{"title":"ACE2-Targeting Monoclonal Antibody as Potent and Broad-Spectrum Coronavirus Blocker","authors":["Chen Yuning","Zhang Yanan","...","Wang 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virus entry","authors":["Junsong Zhang","Feng Huang","...","Hui Zhang"],"journal":"Signal transduction and targeted therapy","date":"2021-05-12","pmid":"33980808","doi":"10.1038/s41392-021-00604-5","pmcid":"8113286","cited_by_count":26,"techniques":["Activity Assay","Clone Assay","Concentration Assay","Construct","Control","Derivative Assay","Ex Vivo","Expressing","Flow Cytometry","In Vitro","Incubation","Infection","Isolation","Knockdown","Labeling","Luciferase","Marker","Plasmid Preparation","Purification","Staining","Transfection","Two Tailed Test","Western Blot"],"bioz_score":"93"},{"title":"Human kidney is a target for novel severe acute respiratory syndrome coronavirus 2 infection","authors":["Bo Diao","Chenhui Wang","...","Yongwen Chen"],"journal":"Nature Communications","date":"2021-05-04","pmid":"33947851","doi":"10.1038/s41467-021-22781-1","pmcid":"8096808","cited_by_count":489,"techniques":["Activity Assay","Double Staining","Expressing","Immunofluorescence","Immunohistochemistry","Incubation","Light Microscopy","Staining"],"bioz_score":"94"},{"title":"SARS-CoV-2 Induces Lymphocytopenia by Promoting Inflammation and Decimates Secondary Lymphoid Organs","authors":["Qun Xiang","Zeqing Feng","...","Yongwen Chen"],"journal":"Frontiers in Immunology","date":"2021-04-28","pmid":"33995382","doi":"10.3389/fimmu.2021.661052","pmcid":"8113960","cited_by_count":72,"techniques":["Activity Assay","Avidin-Biotin Assay","Cell Culture","Derivative Assay","Double Staining","Expressing","Incubation","Infection","Plasmid Preparation","Positive Control","Staining"],"bioz_score":"94"},{"title":"Functional and genetic analysis of viral receptor ACE2 orthologs reveals a broad potential host range of SARS-CoV-2","authors":["Yinghui Liu","Gaowei Hu","...","Qiang Ding"],"journal":"Proceedings of the National Academy of Sciences of the United States of America","date":"2021-03-23","pmid":"33658332","doi":"10.1073/pnas.2025373118","pmcid":"8000431","cited_by_count":179,"techniques":["Binding Assay","Clone Assay","Expressing","Flow Cytometry","Incubation","Recombinant","Staining","Transduction"],"bioz_score":"94"},{"title":"A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry.","authors":["Yunkai Zhu","Fei Feng","...","Rong Zhang"],"journal":"Nature Communications","date":"2021-02-17","pmid":"33574281","doi":"10.1038/s41467-021-21213-4","pmcid":"","cited_by_count":192,"techniques":["Binding Assay","Clinical Proteomics","Cytometry","Expressing","Flow Cytometry","Focus Forming Assay","Immunoprecipitation","Incubation","Infection","Labeling","MANN-WHITNEY","Membrane","Quantitative RT-PCR","Recombinant","Staining","Titration","Transmission Assay","Two Tailed Test","Virus","Western Blot"],"bioz_score":"94"},{"title":"SARS-CoV-2 susceptibility of cell lines and substrates commonly used in diagnosis and isolation 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Control","Quantitative RT-PCR","Transduction","Western Blot"],"bioz_score":"93"},{"title":"SARS-CoV-2 Assays To Detect Functional Antibody Responses That Block ACE2 Recognition in Vaccinated Animals and Infected Patients","authors":["Susanne N. Walker","Neethu Chokkalingam","...","Daniel W. Kulp"],"journal":"Journal of Clinical Microbiology","date":"2020-10-21","pmid":"","doi":"10.1128/jcm.01533-20","pmcid":"","cited_by_count":55,"techniques":["Binding Assay","Blocking Assay","Concentration Assay","Enzyme-linked Immunosorbent Assay","Incubation","SPR Assay"],"bioz_score":"94"},{"title":"IgM autoantibodies recognizing ACE2 are associated with severe COVID-19","authors":["Livia Casciola-Rosen","David R. 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